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HIV/AIDS

HIV/AIDS. With NetLogo, AgentSheets, and Stella. Red Blood Cells. Use Hemoglobin to carry oxygen. 5.2x10 6 per cubic millimeter of blood Carry 300% more oxygen than plasma Carries CO 2 and waste away from tissue. White Blood cells. Types of WBCs Neutrophils Eosinophils Basophiles

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HIV/AIDS

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  1. HIV/AIDS With NetLogo, AgentSheets, and Stella

  2. Red Blood Cells • Use Hemoglobin to carry oxygen. • 5.2x106 per cubic millimeter of blood • Carry 300% more oxygen than plasma • Carries CO2 and waste away from tissue.

  3. White Blood cells • Types of WBCs • Neutrophils • Eosinophils • Basophiles • Monocytes • Helper T cells • Cytotoxic T cells • Memory T cells • Suppressor T cells

  4. HIV/AIDS • Human Immunodeficiency Virus • Advanced Immunodeficiency Syndrome • Transferred through direct bodily contact • Attacks Helper T-cells • Can only be transferred through unprotected intercourse and the sharing of needles

  5. Anatomy of the HIV Virus • Gp120 Envelope Protein • Gp41 Envelope Protein • P17 matrix protein • P24 Capsule Protein • Reverse Transcriptase • The Lipid Membrane Image from www.howstuffworks.com

  6. Virus travels through Bloodstream HIV attacks t-cells Killer t-cells destroy affected cells AIDS virus attaches to a CD4 receptor Transcription Reverse Transcription Proteins cut and packaged with RNA Possible Infections Budding new viruses

  7. Stopping The Virus

  8. And now, Shodor Scholars Program presents… Modeling of HIV and Hepatitis B using NetLogo, AgentSheets, and STELLA

  9. Hepatitis B Effects in the Bloodstream and in a Community

  10. Unprotected intercourse Sharing needles Children of infected parents Transmission

  11. Risk Groups • Promiscuity • House hold contacts with an infected person • Children born to infected mothers

  12. Prevention • Hepatitis B vaccine • Safe Intercourse • Personal evaluation of the disease • Hospital testing

  13. Symptoms • Jaundice • Fatigue • Abdominal pain • Loss of appetite • Nausea • Vomiting • Joint pain

  14. Developing Chronic Hepatitis vaccination • 90% of infants affected at birth • 30% of children affected at age 1-5 • 6% of person affected at 5 • Altogether 15-25% of infected persons

  15. Trends and Statistics • Number of infections per year declined since 1980 • Highest rate runs from 20-49% • 30% of infected people don’t show symptoms

  16. Trends and Statistics • The greatest decline occurs in children and adolescents • Effective vaccines available since 1982 • Hepatitis is 100x easier to catch than HIV (AIDS)

  17. Conclusions • As the virus spread, the immune system is weakened.

  18. Conclusions In the two-disease model, the second disease progresses faster. The earlier one begins risky behavior, the more drastic the deaths in community.

  19. Conclusions • Increased deaths also results in increase in risky behavior. • The same conclusions arise from global and local model.

  20. Conclusions • While not necessarily an acceptable societal choice, the models show that higher mortality could lead to lower diseased population

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