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OUT. OUT. OUT. OUT. IN. IN. N. N. C. C. rClaudin-2 136-230. rClaudin-4 136-209. IN. IN. N. N. C. C. Claudin-4. Claudin-2. OUT. OUT. OUT. OUT. IN. IN. N. N. C. C. rClaudin-2 108-230. rClaudin-4 108-209. IN. IN. N. N. C. C.

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  1. OUT OUT OUT OUT IN IN N N C C rClaudin-2136-230 rClaudin-4136-209 IN IN N N C C Claudin-4 Claudin-2 OUT OUT OUT OUT IN IN N N C C rClaudin-2108-230 rClaudin-4108-209 IN IN N N C C Claudin-4 chimera second extracellular loop claudin-4/E2 Claudin-2 chimera second extracellular loop claudin-2/E4 OUT OUT IN IN N N C C Claudin-2 Claudin-4 A B

  2. C Claudin-1D150N N S N D S N D N C Supplemental Fig. 1. Diagrams of claudins, chimeric claudins, claudin C-terminal fragments, and claudin mutants used in this study. (A) Predicted structure of the claudin components of recombinant claudin species used in Fig. 2 experiments. (B) Predicted structure of claudin chimera constructs used in Fig. 2 and 3, noting the change in the ECL-2 of Claudin-2/E4 and Claudin-4/E2. (C) Representation of claudin ECL-2 point mutations, with amino acid change indicated, that were used as soluble rClaudins in Fig. 5 experiments or were stably expressed by Rat1-R12 fibroblast transfectants in Fig. 6 studies. OUT OUT IN N N C Claudin-4N149D C C Claudin-4N149S OUT OUT IN N N Claudin-2S149N

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