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Cancer Care Engineering Colorectal Cancer Gabriela Chiorean, M.D.

Cancer Care Engineering Colorectal Cancer Gabriela Chiorean, M.D. May 27, 2011. Rationale. Perform OMICs of healthy, polyps, cancer Compare OMICs between cancer, polyps and healthy: develop new screening and risk assessment tools

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Cancer Care Engineering Colorectal Cancer Gabriela Chiorean, M.D.

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  1. Cancer Care Engineering Colorectal CancerGabriela Chiorean, M.D. May 27, 2011

  2. Rationale • Perform OMICs of healthy, polyps, cancer • Compare OMICs between cancer, polyps and healthy: develop new screening and risk assessment tools • Analyse changes in OMICs with treatment and correlate with response/toxicity: predictive markers

  3. Schema IUCRO-0221CCE in CRC Blood (Serum) 7 mL red top Metabolomics, vit D S A M P L E S S H I P D R Y I C E • N=810 • Stratification: • Healthy (n=270) • Polyps (n=270) • Cancer (n=270) • stg 1/2 • stg 3 • stg 4 metastatic Blood (Plasma) 21 mL purple top Genomics, lipidomics, glycoproteomics Fresh Tissue 10 mg polyp or 50 mg cancer / 50 mg normal tissue Paraffin-Embedded Tissue MSI, methylation, KRAS, BRAF, p53 8-hr fasting

  4. Samples CollectionHealthy Controls Label specimens Healthy if no polyps/tumor Screening Colonoscopy – GI Clinic Blood Questionnaires N= 5 6/2009 N=74 5/2010 N=109 5/2011

  5. Samples CollectionAdenomatous Polyps Polyps identified Label specimens Polyp Screening Colonoscopy – GI Clinic Blood Questionnaires Tissue procurement/Research specialist -Polyp cut in ½ -Place in tube with no preservative -Freeze at -70oC N= 3 6/2009 N= 65 5/2010 N= 96 5/2011

  6. Samples CollectionCancer Tissue: tumor, normal mucosa Surgery Chemotherapy Follow-up Blood Questionnaires Every 3 months Up to 24 months N= 8 6/2009 N= 34 5/2010 N= 55 5/2011

  7. Sample Acquisition4/2009-5/2011 Cancer total No prior chemo Prior chemo n=55 n=26 n=29 Stage 1 n=6 n=6 0 Stage 2 n=3 n=2 n=1 Stage 3 n=17 n=10 n=7 Stage 4 n=29 n=8 n=21

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