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Wang et al. (2010) Langmuir v26(19)15445-52.

Spatially-controlled immobilization of polyplexes Suzie H. Pun, University of Washington, DMR 0706647. Overall Goal: Developing a system for spatially and temporally controlled delivery of polyplexes (polymer/nucleic acid complexes used for delivery).

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Wang et al. (2010) Langmuir v26(19)15445-52.

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  1. Spatially-controlled immobilization of polyplexesSuzie H. Pun, University of Washington, DMR 0706647 Overall Goal: Developing a system for spatially and temporally controlled delivery of polyplexes (polymer/nucleic acid complexes used for delivery). Top Figure: Spatial Delivery is achieved by specific immobilization of hexahistidine-tagged nanoparticles on Ni-NTA functionalized SAMs. Bottom Figure: Surface plasmon resonance demonstrates that immobilization is specific and requires both the hexahistidine tag on the particles and the Ni-NTA on the surface Temporal delivery is achieved because cellular uptake requires releasing agents imidazole and EDTA . Wang et al. (2010) Langmuir v26(19)15445-52.

  2. Spatially-controlled immobilization of polyplexesSuzie H. Pun, University of Washington, DMR 0706647 (Right) The Pun laboratory continues to mentor undergraduate researchers in the laboratory. Our efforts were recently highlighted by Amgen Scholars. (Left) The Pun Laboratory presents for University of Washington’s Math Academy, a program that supports ~30 high school juniors from underrepresented minority backgrounds in a 4-week residential session at UW. The Pun lab prepared lectures and several hands on demonstrations.

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