1 / 2

Activation and Inactivation of the Sodium Channel

Activation and Inactivation of the Sodium Channel. SIGMA-ALDRICH. Activation And Inactivation Of The Sodium Channel

meghan
Télécharger la présentation

Activation and Inactivation of the Sodium Channel

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Activation and Inactivation of the Sodium Channel SIGMA-ALDRICH

  2. Activation And Inactivation Of The Sodium Channel Sodium channels are characterized by voltage-dependent activation, rapid inactivation, and selective ion conductance. Depolarization of the cell membrane opens the ion pore allowing sodium to passively enter the cell down its concentration gradient . The increase in sodium conductance further depolarizes the membrane to near the sodium equilibrium potential. Inactivation of the sodium channel occurs within milliseconds, initiating a brief refractory period during which the membrane is not excitable. The mechanism of inactivation has been modeled as a “hinged lid” or “ball and chain”, where the intracellular loop connecting domains III and IV of the a subunit closes the pore and prevents passage of sodium ions. References: Lehmann-Horn, F., and Jurkat-Rott, K., Voltage-gated ion channels and hereditary disease. Physiol. Rev., 79, 1317-1372 (1999). Catterall, W.A., From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron, 26, 13-25 (2000).

More Related