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3-D Multi-Species Biofilm Models

3-D Multi-Species Biofilm Models. F. Gao, X. Zhong, H. La, S. Krone, L. Forney. Model based on nutrient diffusion and energy allocation. (1). (3). (2). nutrient diffusion. Nutrient concentration in bulk liquid is set to be constant and normalized to 1.0;

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3-D Multi-Species Biofilm Models

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  1. 3-D Multi-Species Biofilm Models F. Gao, X. Zhong, H. La, S. Krone, L. Forney

  2. Model based on nutrient diffusion and energy allocation (1) (3) (2)

  3. nutrient diffusion • Nutrient concentration in bulk liquid is set to be constant and normalized to 1.0; • Nutrient diffuses vertically through biofilm, from top down; • A site obtain nutrients diffusing from a cone-shaped region above the site a site

  4. Birth rate 1 Maintenance 2 Energy Nutrient Stress response ATP Conversion coefficient 3 Growth • Allows multiple nutrients • Metabolism • Effects of environment on growth rate

  5. Placement of offspring • Growth is suppressed if all neighboring sites are occupied • Daughter cell placed at vacant direct neighbor chosen at random • If no direct neighbors available, 2nd direct neighbors considered 6 direct nbrs 26 2nd direct nbrs 6 direct nbrs 26 2nd direct nbrs

  6. Death rate • Death rate increased if a cell fails to get enough energy for maintenance and stress response • Death rate is proportional to the gap between the energy demand & actual energy available

  7. Collapse • Maximum thickness • Self regulation before after

  8. simulations • 3 species: 2 aerobic and 1 anaerobic • 2 aerobic species • 2 species: 1 aerobic and 1 anaerobic • randomly initialized

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