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Enoxaparin versus Tinzaparin in Non-ST-segment Elevation Acute Coronary Syndromes: The EVET Trial

Enoxaparin versus Tinzaparin in Non-ST-segment Elevation Acute Coronary Syndromes: The EVET Trial. Michalis LK, Katsouras CS, Papamichael N, Adamides K, Naka KK, Goudevenos J, Sideris DA. Am Heart J. 2003 Aug;146(2):304-10. EVET.

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Enoxaparin versus Tinzaparin in Non-ST-segment Elevation Acute Coronary Syndromes: The EVET Trial

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  1. Enoxaparin versus Tinzaparin in Non-ST-segment Elevation Acute Coronary Syndromes:The EVET Trial Michalis LK, Katsouras CS, Papamichael N, Adamides K, Naka KK, Goudevenos J, Sideris DA. Am Heart J. 2003 Aug;146(2):304-10

  2. EVET 438 patients with non-ST-segment elevation acute coronary syndromes (NSTACS) Single center, open-label randomized trial • Enoxaparin • Subcutaneous 100 IU/kg 2x daily • Equivalent to 1 mg/kg 2x daily • (n = 220) • Tinzaparin • 175 IU/kg once daily • (n = 218) • Endpoints: • Primary – Composite of recurrent angina, MI or death at day 7 • Secondary – Primary endpoint at day 30 and the individual events at days 7 and 30 Am Heart J 2003;146(2):304-10

  3. EVET: Primary Composite Endpoint at Day 7 Death, MI, Recurrent Angina p=0.015 % Am Heart J 2003;146(2):304-10

  4. EVET: Components of Composite Endpoint at Day 7 Recurrent Angina p<0.05 Death p=NS MI p=NS % Am Heart J 2003;146(2):304-10

  5. EVET: Primary Composite Endpoint at Day 30 Death, MI, Recurrent Angina p=0.012 % Am Heart J 2003;146(2):304-10

  6. EVET: Components of Composite Endpoint Day 30 Recurrent Angina p<0.05 Death p=NS MI p<0.05 % Am Heart J 2003;146(2):304-10

  7. EVET: Revascularization at Day 7 and Day 30 Day 30 p=0.019 Day 7 p=0.010 % Am Heart J 2003;146(2):304-10

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