1 / 11

Reaching for a Cure

Reaching for a Cure. Summer 2007 (Group 14) Group Members: Jessica Barnard William Goode Julienne Kung Philippe Lacasse Sarah Pettyjohn. Reaching for Knowledge. Genetic disorders are the result of deleterious mutations in the human genome.

milo
Télécharger la présentation

Reaching for a Cure

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Reaching for a Cure Summer 2007 (Group 14) Group Members: Jessica Barnard William Goode Julienne Kung Philippe Lacasse Sarah Pettyjohn

  2. Reaching for Knowledge • Genetic disorders are the result of deleterious mutations in the human genome. • They cause the synthesis of non-functional or less efficient proteins. • Genetic disorders are caused by the person’s genes where genetic predisposition increases the probability of a disease occurring. • The traditional approach was to treat the symptoms. A modern trend has focused on the source of the problem, the genes themselves.

  3. Today: Cure by Prevention • Prenatal Diagnosis • Microarrays (“Gene Chips”) • Donor Gametes/Embryos • Anonymous Donor Screening • Sperm Separation • Preimplantation Genetic Diagnosis • Polar Body Biopsy • Blastocyst Biopsy

  4. Tomorrow: Moderating Nature • Influencing the Central Dogma • Drugs • Environmental Control

  5. Tomorrow: Modifying Nature • Germline Gene Therapy • General Overview • Insertion of Artificial Chromosomes • Ooplasmic Transfer

  6. Now: Adjusting Life • Use drugs to suppress effects of dysfunction. • Remove affected cells if possible, otherwise… • Make the patient as comfortable as possible by treating symptoms as much as possible. • Consider the balance of longevity and standard of living.

  7. Later: Editing Genes • Gene Therapy • Viral Insertion • Chemical Insertion (“Naked DNA”) • Extraction of Somatic Cells, Genetic Engineering and Re-introduction

  8. Later: Altering Body Composition • Stem Cells • Repopulating areas deficient in certain cells. • Oral Therapies • Injection Therapies • Cell Grafts • Moving healthy cells where they are needed.

  9. Grasping Knowledge • As for prenatal treatment, the most effective method of cure is prevention. Most options include careful family planning. • After the individual is born, medicine will eliminate the disease if possible, but usually, we simply treat symptoms. • In the future, we hope to be able to adjust the human genome to eradicate diseases entirely.

  10. Works Cited • "DNA Chip Technology." DNA Microchip Technology. 8 May 2007. The National Human Genome Research Institute. 11 July 2007 <http://www.genome.gov/10000205>. • "Gene Therapy for Cancer: Questions and Answers." National Cancer Institute Factsheet. 31 Aug. 2006. National Cancer Institute. 12 July 2007 <http://www.cancer.gov/cancertopics/factsheet/Therapy/gene>. • "NINDS Huntington's Disease Information Page." 13 Feb. 2007. 11 July 2007 <http://www.ninds.nih.gov/disorders/huntington/huntington.htm> • "NINDS Muscular Dystrophy Information Page." 13 Feb. 2007. 11 July 2007 <http://www.ninds.nih.gov/disorders/md/md.htm> • “Gene Therapy”. Oxford Illustrated Companion to Medicine . (2001): 334. Ebscohost . 3 July 2007. • “Germline Gene Therapy.” UCLA Program on Science Technology and Society. 20 Mar. 1998. 10 July 2007 <http://www.ess.ucla.edu/huge/germdef.html>. • Cohen, Jacques et al. “Ooplasmic transfer in mature human oocytes” Molecular Human Reproduction vol. 4 no. 3 <http://molehr.oxfordjournals.org/cgi/reprint/4/3/269.pdf> • De Wolfe, Erick. Gene Therapy: A new generation of molecular medicine 5 July 2007 <http://www.cc.ndsu.nodak.edu/instruct/mcclean/plsc431/students/dewold.htm>. • Edwards, D. “Future ‘Patchwork’ Cure for Hemophilia?” Science News . 131 (1987): 168-167. Ebscohost . 3 July 2007. • Genetic Disorders: PTC 124. PTC Therapeutics. 5 July 2007 <http://www.ptcbio.com/3.1.1_generic_disorders.aspx> • Jones, Dan. "Superimmune." New Scientist (2007): 42-45. ISI Web of Knowledge. Georgia Tech Library. 1 July 2007. • Jones, Peter. “Towards a Cure.” Living with Haemophilia . (2002): 253-262. Ebscohost . 3 July 2007. • Jones, Shirley L., and Lee A. Fallon. "Reproductive Options for Individuals At Risk for Trasmission of a Genetic Disorder." Jognn: Clinical Issues 31 (2002): 193-199. ISI Web of Knowledge. Georgia Tech Library. 1 July 2007. • Jonietz, Erika. “Chromosome Cure”. Technology Review . 106 (2003): 29. Ebscohost . 3 July 2007. • Peter, Kennedy. "Potential Use of Herpes Simplex Virus (HSV) Vectors for Gene Therapy of Nurological Disorders." Brain (1997): 1245-1259. ISI Web of Knowledge. Georgia Tech Library. • Silverstein, Alvin; et al. “Chapter Six: Cells and the Future”. Cells . (2002): 47. Ebscohost . 3 July 2007. • Thompson, James S. Genetics in Medicine 3rd ed. Philadelphia: Saunders, 1980

  11. Images Cited Slide 1 • http://www2.carthage.edu/~pfaffle/hgp/genome.jpeg Slide 2 • http://nanopedia.case.edu/image/dna.jpg Slide 3 • http://www.yorku.ca/kdenning/images/bioanthropology/DNAKit_illustration_image.jpg • http://keck.med.yale.edu/affymetrix/technology.htm Slide 4 • http://www.ptcbio.com/3.1.1_generic_disorders.aspx • http://www.cnn.com/SPECIALS/2005/cnn.25/interactive/gallery.medical/1.genome.jpg Slide 5 • http://www.sgeier.net/fractals/flam3/fractals/DNA.jpg • http://www.em1.molmed.uni-erlangen.de/AGSchneider/JEB.html Slide 6 • www.hgsc.bcm.tmc.edu/graphics/genome3.jpg Slide 7 • http://www.esa.int/images/CHROMOSOME400.JPG • http://ghr.nlm.nih.gov/handbook/illustrations/therapyvector Slide 8 • http://www.csa.com/discoveryguides/stemcell/overview.php • http://www.mcdonald.k12.oh.us/home/students/07dugad/Biology%20Project/chromosome_3d.gif Slide 9 • http://digitalartmuseum.com/october/billingsley/artwork/DNA-synthesis.billingsley.jpg Slide 10 • http://english.pravda.ru/img/idb/21-human_genes.jpg Slide 11 • http://archives.cnn.com/2000/HEALTH/06/27/genome.01/story.human.genome.3.jpg

More Related