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Correlation of PRDM1 Mutations and Survival in DLBCL

This study investigates the correlation between PRDM1 mutations and survival outcomes in Diffuse Large B-cell Lymphoma (DLBCL). The impact of PRDM1 mutations on BLIMP-1 protein expression is also examined. Gene expression profiling analysis is performed to identify differentially expressed genes associated with BLIMP-1 expression and PRDM1 mutations.

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Correlation of PRDM1 Mutations and Survival in DLBCL

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  1. Supplementary Figure S1 b a d c Months Months Supplementary Figure S1. Lack of significant correlations with survival outcomes for PRDM1 mutations (MUT) in overall DLBCL (a and b) and in GCB-DLBCL (c and d). WT, wild-type.

  2. Supplementary Figure S2 b a d c Months Months Supplementary Figure S2. PRDM1 mutations within exon 1 or 2 correlated with poor survival in the overall DLBCL cohort (a and b) but not in the GCB-DLBCL subset (c and d). WT, wild-type.

  3. Supplementary Figure S3 b a Supplementary Figure S3. BLIMP-1 protein expression levels with diverse types of PRDM1 mutation.(a)Lower BLIMP-1 protein expression in DLBCLs with nonsense PRDM1 mutations (or truncating mutations, Trunc MUT) than in DLBCLs with wild-type (WT) PRDM1 (P value not significant). The presence of other mutations had no impact on BLIMP-1 protein expression. (b)Lower BLIMP-1 protein expression in DLBCLs with PRDM1 mutations within exons 1 and 2 (Exon 1-2 MUT) than in DLBCLs with wild-type (WT) PRDM1 (P value not significant). The presence of mutations in exons 3-7 (Exon 3-7 MUT) PRDM1 had no impact on BLIMP-1 protein expression. IHC, immunohistochemistry.

  4. Supplementary Figure S4 a b c d e f Months Months Supplementary figure S4. BLIMP-1 protein expression did not correlate with survival outcomes in DLBCL (a and b), ABC-DLBCL (c and d), and GCB-DLBCL (e and f).

  5. Supplementary Figure S5 a b BLIMP-1+ GCB BLIMP-1– GCB MUT-TP53 BLIMP-1+ MUT-TP53 BLIMP-1– CFLAR CALM1 IRF4 GBP5 STAT3 LPCAT2 PRDM1 MLKL CMAH PRDM1 ELL2 CARS USP47 SERPINB1 CARS DIP2A DUSP4 SUB1 HLA-F CTLA4 C1orf38 STX12 ACSL1 SSB1 NEAT1 SDHC BCL11A RALGPS2 INSM1 PATZ1 DIO2 FUSIP1 c d WT-TP53 BLIMP-1+ WT-TP53 BLIMP-1– WT-PRDM1 MUT-PRDM1 exon 1/2 STX6 BTD PPP2R3A LANCL2 ATG9B DNAJB9 SSX2 TRIML2 MAZ SSR4 LAX1 CASP10 HSP90B1 FAM46C TRIM10 XBP1 TP53AIP1 IGJ DEFB121 DNAJC3 SLURP1 PRDM1 IRF1 PRF1 GCNT2 SWAP70 DNAJC10 PTK2 BCL11A IRF6 STA3GAL2 TIAL1 IKZF1 PTEN MS4A1 SOCS4 Supplementary Figure S5. Gene expression profiling analysis. (a) Differentially expressed genes between BLIMP-1+ and BLIMP-1− GCB-DLBCL (false discovery rate [FDR] < 0.15). (b) Differentially expressed genes between BLIMP-1+ and BLIMP-1− DLBCL with mutated TP53 (FDR < 0.20). (c) Differentially expressed genes between BLIMP-1+ and BLIMP-1− DLBCL with wild-type TP53 (FDR < 0.20). (d) Differentially expressed genes between cases with wild-type PRDM1 and those with mutated PRDM1 exon 1 or 2 (FDR < 0.05).

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