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A correlative study for POP of target-based drugs using gene expression cDNA array

A correlative study for POP of target-based drugs using gene expression cDNA array Pharmacology Division, National Cancer Center Research Institute Kazuto Nishio. 775 genes. Up. Down. Zero. Missing.

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A correlative study for POP of target-based drugs using gene expression cDNA array

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  1. A correlative study for POP of target-based drugs using gene expression cDNA array Pharmacology Division, National Cancer Center Research Institute Kazuto Nishio

  2. 775 genes Up Down Zero Missing Clustering and Q-Q plot analysis of gene alteration in PBL samples of target based drug-treated patients Clustering Q-Q-plot Post(Day 8） / Pre(Day 1） 8 7 6 5 4 -log P 3 2 1 0 0 1 2 3 4 5 6 7 8 Savage Score

  3. PRIN 3 0.6 200 mg b.i.d. cluster 0.4 0.2 0 PRIN 1 300 mg b.i.d. cluster -0.2 -0.4 400 mg b.i.d. cluster -0.6 Principal component analysis 3D Elgenvector plot 200 mg b.i.d. 300 mg b.i.d. PRIN 3 -0.8 0 0.1 0.2 0.3 0.4 0.5 40 20 PRIN 1 0 -20 400 mg b.i.d. -40 Signaｌ -60 -80 80 0 20 40 60

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