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Identification of novel parvovirus B19 variants

Identification of novel parvovirus B19 variants. Lori Rinckel, PhD Talecris Biotherapeutics Raleigh Test Laboratory Nucleic Acid Technology Development. Detection of novel B19 variants. Investigational assay developed in house for parvovirus B19 research studies

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Identification of novel parvovirus B19 variants

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  1. Identification of novel parvovirus B19 variants Lori Rinckel, PhD Talecris Biotherapeutics Raleigh Test Laboratory Nucleic Acid Technology Development

  2. Detection of novel B19 variants • Investigational assay developed in house for parvovirus B19 research studies • Assay performance assessed by testing clinical samples in parallel with test of record • Assessment identified several novel variants of parvovirus B19 CONFIDENTIAL

  3. B19 WT Genotype 1 E3 A6 Variant Genotype 2 V9 Variant Genotype 3 D91.1 Variant Genotype 3 Parvovirus B19 Variant ‘E3’ E3 = Genotype 1 variant: CONFIDENTIAL

  4. D11 Parvovirus B19 Variant ‘D11’ D11 = Genotype 1 variant: CONFIDENTIAL

  5. B19 WT Genotype 1 A6 Variant Genotype 2 D91.1 Variant Genotype 3 V9 Variant Genotype 3 P1 Parvovirus B19 Variant ‘P1’ P1 = Genotype 3 variant: Series of donations from same donor also tested CONFIDENTIAL

  6. ‘P1’ Relative Titer CONFIDENTIAL

  7. Parvovirus B19 Phylogeny E3 A6 D11 Variants Variants • Variants differ in DNA sequence by < 10% • Genotypes differ in DNA sequence by ~10% Others ??? Variants Variants V9 P1 D91.1 Candotti et al 2004 CONFIDENTIAL

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