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CONFIDENTIAL

Michael Nagel, President and CEO. CONFIDENTIAL. How Is New Technology Viewed?. “Gee Whiz” has become “So What? ”. The OLD Sales Model & Conversation. Gatekeeper. Hospital. Physician. Patient. Sales Rep. The Story: Technology Features, Benefits, Advantages.

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CONFIDENTIAL

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  1. Michael Nagel, President and CEO CONFIDENTIAL

  2. How Is New Technology Viewed? “Gee Whiz” has become “So What?”

  3. The OLD Sales Model & Conversation Gatekeeper Hospital Physician Patient Sales Rep The Story: Technology Features, Benefits, Advantages

  4. A New Sales Model & Conversation Gatekeepers The Story: Cost-benefit, Economic Feasibility, Risk Sharing, ‘Added Value’ Hospital Physician Patient Sales Rep Corp Accts GPO IDN GOVT Outpatient Facility Long Term Care Facility

  5. Procellera Technology is the first of its kindmicrocurrent generating antimicrobial wound dressing Elemental Silver Imbedded in the dressing are wireless microcell batteries Elemental Zinc In the presence of a conductive fluid (i.e. saline, hydrogel, wound exudate) batteries are activated and generate microcurrents at the dressing surface

  6. Today’s Environment … • More capital investment required • More time – less room for errors • More evidence required • More decision makers • Less investment capital available … calls for a different approach

  7. What Builds Value For Stakeholders? • Potential market size • Clinical value • Patents • Margins • Share of market AND economic viability of technology

  8. Today’s Strategic Outlook Partnerships may be KEY to future technologies Top / Bottom Line Growth Strategic Plans Tactical Execution Studies must aim at demonstrating BOTHclinical and economic value Technology Evidence Key hires and abilities needed at this stage Infrastructure Funding

  9. Inspired by the body. Powered by electricity. Energized by results. Scientific & Clinical Evidence

  10. Research Collaborators

  11. Broad Scientific and Clinical InterestGROWING BODY OF EVIDENCE 7 Publications & 49 Peer Reviewed Abstracts

  12. Reduced Healing Time RETROSPECTIVE CLINICAL STUDY • NOTE: Multicenter retrospective study; N=38 (SOC n=20, Procellera n=18) • Acute & chronic, partial & full-thickness wounds Day 0 Week 3 Whitcomb E, Monroe N, Hope-Higman J, Campbell P. Demonstration of a Microcurrent-Generating Wound Care Device for Wound Healing within a Rehabilitation Center Patient Population. Journal of the American College of Clinical Wound Specialists 2013; 4(2):32-39.

  13. Clinical & Cost Efficacy Studies with Procellera • Tribal Healthcare Facility • Acute /chronic wounds, retrospective; N=18 • Findings: Reduced cost/cm2 to heal vs. skin substitutes, NPWT; 47% reduced time to heal • St. Luke’s Medical Center • Total Knee Arthroplasty, Retrospective; N=100 • Findings: Reduced LOS, readmission and infection rates vs. published literature Reduced LOS Reduced Infection & Readmission Rates 3.5 Days 2.4 Days Chow et al, Orthopedics 2014. Manuscript in submission. Yamada et al, SAWC 2014

  14. Clinical & Cost Efficacy of Procellera + NPWT • Acute surgical wounds, prospective, N=30 • Interim Findings: 22% cost savings in NPWT costs and 33% cost savings in narcotic analgesic costs, vs. NPWT alone • Reduced healing timesand reduced dressing changes Reduced Cost Improved Closure Rates vs. NPWT alone # of Participants Barki, Das, Schlangeret al. Bioelectric Dressing Reduces Cost of Care for Ipatients with Acute Surgical Wounds Treated with NPWT. In: 7th Annual Translational to Clinical Regenerative Medicine Wound Care Conference, Columbus, OH. March 2014.

  15. GPO Contract Status August 1, 2014

  16. New Model For Winning Teams • Diverse strengths and backgrounds – no duplicity • Wide use of consultants – best in class • Engaged employees that connect to the mission • Flexibility and speed to market

  17. New Model for Device Companies • Companies must operate leaner • Substance over “fluff” • Studies must be well designed and strategy carefully thought out • Clear line of sight to core competencies • Rethink traditional sales models • Service (‘value-add’) takes on new importance • Partnership considerations

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