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ENZIM TERKAIT INFLAMASI

ENZIM TERKAIT INFLAMASI . KELOMPOK 1 Nurina Khimatus S (G1F011022) Ruth Febrina (G1F011006) Dedah Nurhamidah (G1F011008) Inas Ghausani (G1F011012) Khilman Husna (G1F011036) Windhiana Sapti (G1F011038) Muhammad Rifki Hadafi (G1F011042) Vidya Nur A (G1F011048)

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ENZIM TERKAIT INFLAMASI

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  1. ENZIM TERKAIT INFLAMASI KELOMPOK 1 Nurina Khimatus S (G1F011022) Ruth Febrina (G1F011006) Dedah Nurhamidah (G1F011008) Inas Ghausani (G1F011012) Khilman Husna (G1F011036) Windhiana Sapti (G1F011038) Muhammad Rifki Hadafi (G1F011042) Vidya Nur A (G1F011048) Aisyah Putriani (G1F011050)

  2. How is inflamation? Rangsangan Nyeri Glukokortikoid Membran fosfolipid Fosfolipase A2 Asam arakhidonat NSAID Lipooksigenase (LOX) Siklooksigenase (COX) Endoperoksida siklik 5-HPETE Celecoxib COX-1 COX- 2 LTA4, LTB 4,LTC4, LTD4, LTE4 TXA2 PG PG Protasiklin

  3. Perbedaan COX 1 dan COX 2 COX 1 dan COX 2 dalam bentuk bedanya pada rantai asam amino pada posisi 523 untuk COX 1 (isoleusin), COX 2 (valin)

  4. AKSI KERJA OBAT STEROID E.Fospolipase As.Arakidonat SUBSTRAT AINS E.Siklooksigenasese A. Arakidonat Prosta-glandin Prostasiklin Tromboksan A2 Coxib E.Siklooksigenase 2 Prosta-glandin Prostasiklin As. Arakidonat

  5. EFEK SAMPING OBAT COX1 ->Tromboxan A2 Selektif (celecoxib) Trombosis x COX 2 -> Prostasiklin LOX-> Leukotrien NSAID Asma x COX Non Selektif (Aspirin) x COX 1 -> Prostaglandin Tukak Lambung x COX 2 Tromboxan A2 → agregasi platelet & vasokonstriksi Prostasiklin → inhibitor agregasi platelet & vasodilator Leukotrien → bronkokonstriksi Prostaglandin COX1 → pelindung mukosa lambung

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