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Presentation on. Agonist antagonist. Agonist:. Agonist is a drug or ligand that can bind or combine with with a receptor activates and the receptor. Example: 1.Apomorphine (Direct acting agonist) 2.Cocaine (Indirect acting agonist). Figure of Apomorphine and cocaine. Potency of agonist.

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  1. Presentation on Agonist antagonist www.AssignmentPoint.com

  2. Agonist: Agonist is a drug or ligand that can bind or combine with with a receptor activates and the receptor. Example: 1.Apomorphine (Direct acting agonist) 2.Cocaine (Indirect acting agonist) www.AssignmentPoint.com

  3. Figure of Apomorphine and cocaine www.AssignmentPoint.com

  4. Potency of agonist • The potency of any agonist is inversely related to its Ec₅₀ value. (Ec₅₀ is term half maximize effective concentration of a drug refers to the concentration of a drug). www.AssignmentPoint.com

  5. Types of agonist • Physiological agonist • Endogenous agonist • Super agonist • Full agonist • Partial agonist • Inverse agonist • Irreversible agonist www.AssignmentPoint.com

  6. Definition of these types • Physiological agonist: It is a substance that creates the same bodily responses but does not bind the receptor. • Endogenous agonist: It is a compound naturally produced by the body that activates the receptor. • Super agonist: It is a compound that is capable of producing a greater maximal response than the endogenous agonist for the target receptor. www.AssignmentPoint.com

  7. Definition of these types • Full agonist: It activates a receptor displaying full efficacy. • Partial agonist: It also bind and activate a given receptor at the receptor but have only partial efficacy at the receptor relative to a full agonist. • Inverse agonist: It is an agent that binds to the same receptor binding site as an antagonist for that receptor and reverses the constitutive activity of receptors. www.AssignmentPoint.com

  8. Where does mechanism happen? www.AssignmentPoint.com

  9. Mechanism www.AssignmentPoint.com An agonist is any drug that binds to receptor and activates the receptor. Oppositely antagonist is any drug that binds to a receptor and prevents the activation of the receptor.

  10. Mechanism Competitive antagonist: A competitive antagonist is any pharmacologic antagonist that competes with the binding of agonist at the binding site. If we add more and more agonist eventually we can win the competition and reach maximum effect. www.AssignmentPoint.com

  11. Mechanism Non competitive antagonist: It is any pharmacological antagonist that binds to a site on the receptor other than the agonist binding site. Then no matter how much agonist we add eventually we can not win the competition and reach maximal effect. www.AssignmentPoint.com

  12. Antagonist The antagonist word has come from Greek. It means opponents, enemy. A pharmacological antagonist is any drug that binds to a receptor and prevents the activation of the receptor. www.AssignmentPoint.com

  13. Example • Haloperidol (Direct acting antagonist) • alpha-methyl-para-tyrosin and reserpine (Indirect acting antagonist) www.AssignmentPoint.com

  14. Figure of Haloperidol tablet www.AssignmentPoint.com

  15. Types • Non competitive antagonist • Uncompetitive antagonist • Silent antagonist www.AssignmentPoint.com

  16. Definition of these types • Non competitive antagonist: A noncompetitive antagonist is any pharmacologic antagonist that binds to a site on the receptor other than the agonist binding site www.AssignmentPoint.com

  17. Definition of these types • Uncompetitive: Uncompetitive antagonist differs from noncompetitive antagonist is that they require receptor activation by an agonist before they can bind to a separate allostric binding site. • Silent antagonist: Silent antagonists are competitive receptor antagonists that have zero intrinsic activity for activating a receptor. www.AssignmentPoint.com

  18. That`s All.... www.AssignmentPoint.com

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