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H 2 O 2

OUT. IN. e -. e -. e -. e -. e -. e -. e -. e -. . OH. GPx. H 2 O 2. H 2 O 2. +. Cyt C. Cyt C. Cyt C. Fe 2+. Cat. e -. e -. O 2. O 2. O 2. O 2. O -. O -. ADP. ATP. Q. H 2 O. H 2 O. Mitochondrial Electron Transport Chain. H + H + H + H + H +. H +.

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H 2 O 2

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  1. OUT IN e- e- e- e- e- e- e- e- .OH GPx H2O2 H2O2 + Cyt C Cyt C Cyt C Fe2+ Cat e- e- O2 O2 O2 O2 . . O- O- ADP ATP Q H2O H2O Mitochondrial Electron Transport Chain H+ H+ H+H+H+ H+ H+H+ H+H+ OH- H+H+ H+H+ 2OH- NAD+ H+`H+ H+` MnSOD NADH Krebs Cycle Animated by Peter Rabinovitch Background after Mandavilli et al, Mutation Research 509 (2002) 127–151

  2. Fe-S Fe-S Fe-S Fe-S Apoptosis VDAC Bax Bcl2 CytC CytC NADH Krebs Cycle VDAC Aconitase Fe-S e- work MPTP Pi mtDNA Caspase 9 (active) CytC CytC Caspase 9 (inactive) APAF-1 Background after Mandavilli et al, Mutation Research 509 (2002) 127–151

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