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To Stress or not to stress ?

To Stress or not to stress ?. Karam Paul MS, MD, MBA, FACC Community Heart and Vascular. Cardiac stress testing - learning objectives. ►Know why to undertake a stress test ►Know who should have one ►Know how it is performed ►Understand the limitations ►Understand which to choose

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To Stress or not to stress ?

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  1. To Stress or not to stress ? Karam Paul MS, MD, MBA, FACC Community Heart and Vascular

  2. Cardiac stress testing - learning objectives ►Know why to undertake a stress test ►Know who should have one ►Know how it is performed ►Understand the limitations ►Understand which to choose ►Know what to do with the result

  3. Cardiac stress testing • Why do a stress test?

  4. Aims of stress testing ►Elicit abnormalities not present at rest ►Estimate functional capacity ►Estimate prognosis ►Likelihood of coronary artery disease ►Extent of coronary artery disease ►Effect of treatment

  5. Cardiac stress testing • Who should have one?

  6. Diagnostic test ►Bayes’ Theorem ►Consider the ‘pre-test risk’ ►Sensitivity & specificity of the test ►Post-test probability of CAD ►Diagnostic power of EST is maximal when the pre-test probability is intermediate.

  7. Risk assessment ►Pre-existing coronary artery disease ►Diabetes ►Hypertension ►Smoking history ►Family history ►Renal disease

  8. Consider other risk factors Pre-existing coronary artery disease ►Diabetes ►Hypertension ►Hyperlipidemia ►Smoking history ►Family history ►Renal disease

  9. Consider other risk factors ►Pre-existing coronary artery disease ►Diabetes ►Hypertension ►Hyperlipidemia ►Smoking history ►Family history ►Renal disease

  10. Valvularheart disease

  11. Rhythm disorders

  12. Contraindications

  13. Cardiac Stress Testing How is it done?

  14. Exercise protocol

  15. Positive!

  16. Measurements ►ECG ►Exercise capacity (METS – metabolic equivalent) ►Symptoms ►Blood pressure ►Heart rate response & recovery

  17. ECG  1mm planar ST depression  3 consecutive beats

  18. ► The normal and rapid upsloping ST segment responses are normal responses to exercise. ► Minor ST depression can occur occasionally at submaximal workloads in patients with coronary disease. ► The slow upsloping ST segment pattern often demonstrates an ischemic response in patients with known coronary disease or those with a high pretest clinical risk of coronary disease. ► Downsloping ST segment depression represents a severe ischemic response. ► ST segment elevation in an infarct territory (Q wave lead) indicates a severe wall motion abnormality and, in most cases, is not considered an ischemic response. (From Chaitman BR: Exercise electrocardiographic stress testing. In Beller GA [ed]: Chronic Ischemic Heart Disease. In Braunwald E [series ed]: Atlas of Heart Diseases. Vol 5. Chronic Ischemic Heart Disease. Philadelphia, Current Medicine, 1995, pp 2.1-2.30

  19. T wave changes ► Influenced by:  Body position  Respiration  Hyperventilation  Drug Rx  Myocardial ischemia  Necrosis ► Pseudonormalisation:  Usually non-diagnostic  Consider ancillary imaging

  20. METs

  21. Heart rate response ►Peak HR > 85% of maximal predicted for age ►HR recovery >12 bpm (erect) ►HR recovery >18 bpm (supine)

  22. Heart rate response

  23. Prognostic value of stress testing Parameters associated with adverse prognosis or multi-vessel disease ► Duration of symptom-limiting exercise <5 METs ► Failure to increase sBP ≥120mmHg, or a sustained decreased ≥ 10mmHg, or below rest levels, during progressive exercise ► ST segment depression ≥2mm, downsloping ST segment, starting at <5 METs, involving ≥5 leads, persisting ≥5 min into recovery ► Exercise-induced ST segment elevation (aVR excluded) ► Angina pectoris at low exercise workloads ► Reproducible sustained (>30 sec) or symptomatic ventricular tachycardia

  24. Limitations of treadmill stress test ► Non-diagnostic ECG changes ► False positives/false negatives ► Women – false positives ► Elderly – more sensitive/less specific ► Diabetics – autonomic dysfunction ► Hypertension ► Inability to exercise ► Drugs – digoxin; anti-anginals

  25. Non-coronary causes of ST segment depression ► Anemia ► Cardiomyopathy ► Digoxin ► Glucose load ► Hyperventilation ► Hypokalemia ► Intraventricular conduction disturbance ► Mitral valve prolapse ► Pre-excitation syndrome ► Severe aortic stenosis ► Severe hypertension ► Severe hypoxia ► Severe volume overload (aortic or mitral regurgitation) ► Sudden excessive exercise ► Supraventricular tachycardia's

  26. Limitations of treadmill stress test  Sensitivity 68%  Specificity 77%

  27. Ancillary techniques to enhance content  Echocardiography  Radionuclide imaging

  28. Stress echocardiography

  29. Stress echocardiography Compares pre & post:  Regional contractility  Overall systolic function  Volumes  Pressure gradients  Filling pressures  Pulmonary pressures  Valvular function

  30. Dobutamine stress echo

  31. Stress echo - limitations Factors which effect image quality:  Body habitus  Lung disease  Breast implants

  32. Normal stress echocardiogram

  33. Case 1 ►54 year old bank project manager ►Exertional chest pain & dyspnea ►Ex-smoker ►TC = 6.7mmol/L ►Stress ECG – 2mm ST segment depression in 5 leads

  34. Stress echocardiogram

  35. Coronary angiogram

  36. Case 2 ►62 year old female ►Chest pain & dyspnea ►Treadmill exercise test – non-diagnostic  sub-maximal  Hypertension  No ECG changes

  37. Case 2 ►Exercised 7½ minutes (9.4 METS) ►No chest pain ►ECG changes

  38. Case 2

  39. Case 2

  40. Case 3 ►24 year old female engineer ►Exertionaldyspnea ►Palpitations

  41. Case 3 Inducible dyspnea ►ECG  partial right bundle branch block  no ischemic changes

  42. Case 3

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