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To Stress or not to stress ?. Karam Paul MS, MD, MBA, FACC Community Heart and Vascular. Cardiac stress testing - learning objectives. ►Know why to undertake a stress test ►Know who should have one ►Know how it is performed ►Understand the limitations ►Understand which to choose
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To Stress or not to stress ? Karam Paul MS, MD, MBA, FACC Community Heart and Vascular
Cardiac stress testing - learning objectives ►Know why to undertake a stress test ►Know who should have one ►Know how it is performed ►Understand the limitations ►Understand which to choose ►Know what to do with the result
Cardiac stress testing • Why do a stress test?
Aims of stress testing ►Elicit abnormalities not present at rest ►Estimate functional capacity ►Estimate prognosis ►Likelihood of coronary artery disease ►Extent of coronary artery disease ►Effect of treatment
Cardiac stress testing • Who should have one?
Diagnostic test ►Bayes’ Theorem ►Consider the ‘pre-test risk’ ►Sensitivity & specificity of the test ►Post-test probability of CAD ►Diagnostic power of EST is maximal when the pre-test probability is intermediate.
Risk assessment ►Pre-existing coronary artery disease ►Diabetes ►Hypertension ►Smoking history ►Family history ►Renal disease
Consider other risk factors Pre-existing coronary artery disease ►Diabetes ►Hypertension ►Hyperlipidemia ►Smoking history ►Family history ►Renal disease
Consider other risk factors ►Pre-existing coronary artery disease ►Diabetes ►Hypertension ►Hyperlipidemia ►Smoking history ►Family history ►Renal disease
Cardiac Stress Testing How is it done?
Measurements ►ECG ►Exercise capacity (METS – metabolic equivalent) ►Symptoms ►Blood pressure ►Heart rate response & recovery
ECG 1mm planar ST depression 3 consecutive beats
► The normal and rapid upsloping ST segment responses are normal responses to exercise. ► Minor ST depression can occur occasionally at submaximal workloads in patients with coronary disease. ► The slow upsloping ST segment pattern often demonstrates an ischemic response in patients with known coronary disease or those with a high pretest clinical risk of coronary disease. ► Downsloping ST segment depression represents a severe ischemic response. ► ST segment elevation in an infarct territory (Q wave lead) indicates a severe wall motion abnormality and, in most cases, is not considered an ischemic response. (From Chaitman BR: Exercise electrocardiographic stress testing. In Beller GA [ed]: Chronic Ischemic Heart Disease. In Braunwald E [series ed]: Atlas of Heart Diseases. Vol 5. Chronic Ischemic Heart Disease. Philadelphia, Current Medicine, 1995, pp 2.1-2.30
T wave changes ► Influenced by: Body position Respiration Hyperventilation Drug Rx Myocardial ischemia Necrosis ► Pseudonormalisation: Usually non-diagnostic Consider ancillary imaging
Heart rate response ►Peak HR > 85% of maximal predicted for age ►HR recovery >12 bpm (erect) ►HR recovery >18 bpm (supine)
Prognostic value of stress testing Parameters associated with adverse prognosis or multi-vessel disease ► Duration of symptom-limiting exercise <5 METs ► Failure to increase sBP ≥120mmHg, or a sustained decreased ≥ 10mmHg, or below rest levels, during progressive exercise ► ST segment depression ≥2mm, downsloping ST segment, starting at <5 METs, involving ≥5 leads, persisting ≥5 min into recovery ► Exercise-induced ST segment elevation (aVR excluded) ► Angina pectoris at low exercise workloads ► Reproducible sustained (>30 sec) or symptomatic ventricular tachycardia
Limitations of treadmill stress test ► Non-diagnostic ECG changes ► False positives/false negatives ► Women – false positives ► Elderly – more sensitive/less specific ► Diabetics – autonomic dysfunction ► Hypertension ► Inability to exercise ► Drugs – digoxin; anti-anginals
Non-coronary causes of ST segment depression ► Anemia ► Cardiomyopathy ► Digoxin ► Glucose load ► Hyperventilation ► Hypokalemia ► Intraventricular conduction disturbance ► Mitral valve prolapse ► Pre-excitation syndrome ► Severe aortic stenosis ► Severe hypertension ► Severe hypoxia ► Severe volume overload (aortic or mitral regurgitation) ► Sudden excessive exercise ► Supraventricular tachycardia's
Limitations of treadmill stress test Sensitivity 68% Specificity 77%
Ancillary techniques to enhance content Echocardiography Radionuclide imaging
Stress echocardiography Compares pre & post: Regional contractility Overall systolic function Volumes Pressure gradients Filling pressures Pulmonary pressures Valvular function
Stress echo - limitations Factors which effect image quality: Body habitus Lung disease Breast implants
Case 1 ►54 year old bank project manager ►Exertional chest pain & dyspnea ►Ex-smoker ►TC = 6.7mmol/L ►Stress ECG – 2mm ST segment depression in 5 leads
Case 2 ►62 year old female ►Chest pain & dyspnea ►Treadmill exercise test – non-diagnostic sub-maximal Hypertension No ECG changes
Case 2 ►Exercised 7½ minutes (9.4 METS) ►No chest pain ►ECG changes
Case 3 ►24 year old female engineer ►Exertionaldyspnea ►Palpitations
Case 3 Inducible dyspnea ►ECG partial right bundle branch block no ischemic changes