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Thyroid gland

Thyroid gland. petercelec@gmail.com. Specifics . Iodine is rare Ubiquitary receptors Highly potent action Very common disorders 5% women 0,5% men. Structure. Thyroid gland. Thyroid gland. Thyroid gland. T3, T4 synthesis. T3, T4 metabolism. Iodine intake.

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Thyroid gland

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  1. Thyroid gland petercelec@gmail.com

  2. Specifics • Iodine is rare • Ubiquitary receptors • Highly potent action • Very common disorders • 5% women • 0,5% men

  3. Structure

  4. Thyroid gland

  5. Thyroid gland

  6. Thyroid gland

  7. T3, T4 synthesis

  8. T3, T4 metabolism

  9. Iodine intake • 150 ug – daily intake of iodine • 125 ug – taken up by the thyroid gland • Iodine in the soil – region dependent • Iodide supplementation of salt

  10. Thyroid hormones • In the thyroid gland • 90% T4 • 10% T3 • TBG, transthyretin • In the periphery • 80% T3 • 10% T4 • 10% rT3

  11. Receptors • Membraneboundreceptors

  12. Action • Increase of number and size of mitochondria • Synthesis of respiratory chain enzymes • Na+ K+ ATPase • Uncloupling proteins • Increase in resting metabolic activity

  13. Regulation

  14. Goiter

  15. Hyperthyroidism

  16. Hyperthyroidism

  17. Hyperthyroidism – Grave’s disease

  18. Grave’s disease • Grave’s Basedow trias • Goiter • Exophtalmus • Hyperthyroidism • Autoimmune disease • Anti-TSH receptor

  19. Hypothyroidism

  20. Hypothyroidism

  21. Hypothyroidism • Primary • Thyroid gland • Hashimoto’s disease • Autoimmune thyroid destruction • Creteinism • Neonatal screening • Secondary • Pituitary gland

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