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GRB2

PDGFA: miR-30a /30a-5p/30b/30b-5p/ 30c de/384-5p; miR-135; miR-1/206; miR-23ab ; miR-196ab; miR-153; miR-221 /222; miR-194; miR-141/200a; miR-375

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GRB2

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  1. PDGFA: miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-135; miR-1/206; miR-23ab; miR-196ab; miR-153; miR-221/222; miR-194; miR-141/200a; miR-375 PDGFB: miR-184; miR-17-5p/20/93.mr/106/519.d; let-7/98; miR-143; miR-29abc; miR-122; miR-204/211; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-31; miR-150; miR-139-5p; miR-19 miR-499/499-5p; miR-199/199-5p; miR-150; miR-19; miR-145 PDGF miR-425/489; miR-365; miR-33/33ab; miR-146 PDGFRA: miR-141/200a; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-17-5p/20/93.mr/106/519.d; miR-146; miR-181; miR-33/33ab; miR-182; miR-219/219-5p; miR-218; miR-128; miR-27ab; miR-24; miR-137; miR-130/301; miR-29abc; miR-455/455-5p; miR-26ab/1297; miR-203; miR-140/140-5p/876-3p; miR-196ab; miR-96/1271; miR-204/211; miR-132/212; miR-375; miR-129/129-5p; miR-143; miR-25/32/92/92ab/363/367; miR-216/216a; miR-193ab; miR-10; miR-139-5p; miR-153; miR-499/499-5p; miR-9; miR-490/490-3p; miR-383; miR-122 PDGFRB: miR-24; miR-9; miR-204/211; miR-338/338-3p; miR-18ab; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-29abc; miR-499/499-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-146; miR-124/506; miR-17-5p/20/93.mr/106/519.d; miR-143; miR-129/129-5p; miR-19; miR-138; miR-365; miR-208/208ab; miR-141/200a; miR-31; miR-181; miR-193ab; miR-223; miR-150; miR-135; miR-122 miR-99ab/100; miR-194; miR-101; miR-145; miR-153; miR-31; miR-18ab; miR-23ab; miR-15/16/195/424/497; miR-22; miR-125/351; miR-503; miR-214/761; miR-24; miR-10; miR-132/212; miR-103/107; miR-29abc; miR-181; miR-19 miR-7/7ab; miR-27ab; miR-106/302; miR-141/200a; miR-133; miR-155; miR-101; miR-365; miR-455/455-5p; miR-1/206; miR-128; miR-103/107; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-129/129-5p; miR-144; miR-218 SHC1: miR-9; miR-204/211; miR-218; miR-124/506; miR-203; miR-139-5p; miR-18ab; miR-150; miR-200bc/429; miR-219/219-5p; miR-96/1271; miR-153; miR-365; miR-22; miR-216/216b; miR-375; miR-10; miR-7/7ab SHC2: miR-9; miR-338/338-3p; miR-218; miR-146 SHC3: miR-192/215; miR-338/338-3p SHC4: miR-129/129-5p; miR-106/302; miR-218; miR-200bc/429; miR-150; miR-182; miR-27ab; miR-203; miR-31; miR-140/140-5p/876-3p; miR-124/506; miR-216/216b; miR-208/208ab; miR-499/499-5p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-96/1271; miR-101; miR-144; miR-216/216a; miR-128; miR-141/200a; miR-137; miR-155; miR-26ab/1297 PLCG 1/2 SHC 1/2/3/4 miR-200bc/429; miR-204/211; miR-135; miR-218; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-182; miR-101; miR-96/1271; miR-1/206; miR-125/351; miR-205; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-214/761; miR-129/129-5p; miR-155; miR-103/107; miR-455/455-5p; miR-223; miR-181 DAG * SOS1: miR-217; miR-204/211; miR-27ab; miR-124/506; miR-148/152; miR-106/302; miR-128; miR-17-5p/20/93.mr/106/519.d; miR-200bc/429; miR-425/489; miR-181; miR-194; miR-365; miR-9; miR-132/212; miR-203; miR-1/206; miR-24; miR-155; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-15/16/195/424/497; miR-451; miR-103/107; miR-129/129-5p; miR-143; miR-101; miR-18ab; miR-375; miR-96/1271; miR-182; miR-23ab; miR-144; miR-455/455-5p; miR-125/351; miR-223 SOS2: miR-148/152; miR-129/129-5p; miR-130/301; miR-193ab; miR-499/499-5p; miR-199/199-5p; miR-21/590-5p; miR-124/506; miR-19; miR-138; miR-15/16/195/424/497; miR-208/208ab; miR-383; miR-204/211; miR-145; miR-214/761; miR-221/222; miR-96/1271; miR-182; miR-135 SPHK1: miR-124/506; miR-1/206 SPHK2: miR-153; miR-130/301; miR-338/338-3p; miR-1/206; miR-19; miR-25/32/92/92ab/363/367; miR-184; miR-137; miR-181; miR-451; miR-503; miR-383; miR-15/16/195/424/497; miR-31 SPHK 1/2 KRAS: miR-181; miR-27ab; miR-143; miR-217; miR-96/1271; miR-132/212; miR-155; miR-193ab; miR-19; miR-365; miR-199/199-5p; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-141/200a; miR-216/216b; miR-1/206; miR-425/489; miR-129/129-5p; miR-214/761; miR-146; miR-383; miR-190; miR-204/211; miR-23ab; miR-15/16/195/424/497; miR-200bc/429; miR-216/216a; miR-125/351; miR-128; miR-101; miR-218; miR-31; miR-144; miR-7/7ab; miR-194; miR-142-3p; miR-490/490-3p HRAS: miR-338/338-3p miR-181; miR-124/506; miR-96/1271; miR-10; miR-490/490-3p; miR-203; miR-193ab; miR-125/351 miR-7/7ab; miR-19; miR-15/16/195/424/497; miR-125/351; miR-135; miR-455/455-5p; miR-503; miR-139-5p; miR-150; miR-1/206; miR-143 MAP2K 1/2 MAP2K1: miR-181; miR-15/16/195/424/497; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-148/152; miR-144; miR-96/1271; miR-130/301; miR-203; miR-503; miR-139-5p; miR-23ab MAP2K2: miR-503 DAPK1: miR-141/200a; miR-191; miR-26ab/1297; miR-130/301; miR-23ab; miR-143; miR-338/338-3p; miR-124/506; miR-7/7ab; let-7/98; miR-221/222; miR-204/211; miR-383 DAPK2: miR-214/761; miR-129/129-5p; miR-499/499-5p; miR-106/302; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; let-7/98; miR-138; miR-10; miR-17-5p/20/93.mr/106/519.d; miR-25/32/92/92ab/363/367; miR-133; miR-208/208ab; miR-143; miR-122; miR-205 DAPK3: miR-7/7ab; miR-503; miR-128; miR-214/761 DAPK 1/2/3 miR-204/211; miR-128; miR-132/212; miR-23ab; miR-150; miR-30a/30a-5p/30b/30b-5p/30cde/384-5p; miR-27ab; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-190; miR-214/761; miR-10; miR-187; miR-29abc; miR-216/216a; miR-15/16/195/424/497; miR-122; miR-9; miR-125/351 miR-130/301; miR-128; miR-148/152; miR-17-5p/20/93.mr/106/519.d; miR-19; miR-27ab; miR-204/211; miR-203; miR-106/302; miR-18ab; miR-103/107; miR-1/206; miR-425/489; miR-144; miR-455/455-5p; miR-199/199-5p; miR-153; miR-129/129-5p; miR-23ab; miR-21/590-5p FGF3 EGF RAF1 MAPK1 MSK1 RASSF1 PKC PDGFR EGFR GRB2 SOS1/2 FGFR3 RAS miR-27ab; miR-153; miR-141/200a; miR-124/506; miR-15/16/195/424/497; miR-128; miR-96/1271; miR-182; miR-338/338-3p; miR-150; miR-129/129-5p; miR-17-5p/20/93.mr/106/519.d; miR-203; miR-106/302; miR-183; miR-221/222; miR-22; miR-10; miR-199/199-5p; miR-125/351; miR-138

  2. * PRKCA: miR-205; miR-203; miR-199/199-5p; miR-23ab; miR-223; miR-219/219-5p; miR-139-5p; miR-17-5p/20/93.mr/106/519.d; miR-132/212; miR-150; miR-200bc/429;miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-129/129-5p; miR-216/216b; miR-375; miR-15/16/195/424/497; miR-216/216a; miR-22; miR-338/338-3p; miR-141/200a; miR-9; miR-24; miR-183; miR-1/206; miR-193ab; miR-210; miR-125/351; miR-214/761; miR-10; miR-503; miR-181; miR-122; miR-146; miR-138; miR-194; miR-204/211; miR-490/490-3p; miR-192/215; miR-217; miR-7/7ab PRKCB1: miR-183; miR-129/129-5p; miR-203; miR-141/200a; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-194; miR-182; miR-26ab/1297; miR-106/302; let-7/98; miR-365; miR-184; miR-148/152; miR-33/33ab; miR-29abc; miR-7/7ab PRKCD: miR-26ab/1297; miR-181; miR-129/129-5p; miR-490/490-3p; miR-218; miR-27ab; miR-15/16/195/424/497 PRKCG: miR-338/338-3p; miR-503; miR-140/140-5p/876-3p; miR-135; miR-1/206 PRKCE: miR-31; miR-96/1271; miR-129/129-5p; miR-216/216a; miR-101; miR-141/200a; miR-146; miR-205; miR-103/107; miR-1/206; miR-33/33ab; miR-182; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-143; miR-223; miR-10; miR-181; miR-383; miR-144; miR-23ab; miR-22; miR-21/590-5p; miR-132/212; miR-218; miR-216/216b; miR-25/32/92/92ab/363/367; miR-139-5p; miR-106/302; miR-125/351; miR-29abc; miR-19 PRKCH: miR-24; miR-205; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-216/216a; miR-204/211; miR-27ab; miR-17-5p/20/93.mr/106/519.d; miR-145; miR-383; miR-216/216b; miR-221/222; miR-200bc/429; miR-455/455-5p; miR-214/761 PRKCI: miR-203; miR-455/455-5p; miR-103/107; miR-219/219-5p; miR-146; miR-365; miR-10; miR-155; miR-183; miR-199/199-5p; miR-23ab; miR-141/200a;miR-204/211;miR-15/16/195/424/497;miR-129/129-5p;miR-24;miR-33/33ab;miR-200bc/429;miR-96/1271;miR-29abc;miR-1/206;miR-150;miR-490/490-3p;miR-217;miR-138;miR-18ab;miR-216/216a;miR-182;miR-181 PRKCQ: miR-26ab/1297; miR-34a/34b-5p/34c/34c-5p/449/449abc/699; miR-192/215; miR-25/32/92/92ab/363/367; miR-203; miR-183; miR-193ab; miR-221/222; miR-137; miR-31; miR-214/761; miR-383; miR-200bc/429 PRKCZ: miR-148/152; miR-15/16/195/424/497; miR-338/338-3p; miR-503 Supplemental Figure 4. Overview of Growth Factor Receptor signaling. Summary of Growth Factor Receptor signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in bladder cancer are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplemental Table 5.

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