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Upbeat Nystagmus

917-5. Upbeat Nystagmus. Eye Movements. Upbeat nystagmus in primary gaze Horizontal gaze evoked nystagmus left > right No nystagmus on downgaze Saccadic pursuit in all directions. Square wave jerks. Dysmetria. Marked saccadic hypermetria

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Upbeat Nystagmus

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  1. 917-5 Upbeat Nystagmus

  2. Eye Movements Upbeat nystagmus in primary gaze Horizontal gaze evoked nystagmus left > right No nystagmus on downgaze Saccadic pursuit in all directions. Square wave jerks

  3. Dysmetria Marked saccadic hypermetria Right gaze to center overshoot (hypermetria) taking the eyes almost fully to the left Left gaze to center (hypermetria) taking the eyes almost fully to the right Upgaze to center hypermetria Downgaze to center hypermetria

  4. Clinical Features of Upbeat Nystagmus Present in primary gaze usually increases on upgaze Slow phases may have linear-, increasing-, or decreasing-velocity waveforms Poorly suppressed by visual fixation of a distant target

  5. Clinical Features of Upbeat Nystagmus Convergence may increase, suppress or convert to downbeat nystagmus Associated with abnormal vertical vestibular and smooth-pursuit responses, and saccadic intrusions (square-wave jerks) that produce a bow-tie nystagmus

  6. Upbeat Nystagmus Localizes to the Caudal Medulla with the lesion affecting the perihypoglossal group of nuclei including: nucleus intercalatus nucleus of Roller nucleus of pararaphales

  7. Upbeat Nystagmus More rostral brainstem lesions may interrupt the ventral tegmental tract containing projections from the vestibular nuclei that receive inputs from the anterior semicircular canal or Involve the brachuim conjunctivum in the rostral pons and medulla.

  8. Etiology of Upbeat Nystagmus Infarction of medulla or cerebellum and superior cerebellar peduncle Wernicke’s encephalopathy Multiple sclerosis Tumors of the medulla, cerebellum or midbrain Cerebellar degeneration or anomalies

  9. Etiology of Upbeat Nystagmus Brainstem encephalitis Creutzfeldt-Jacob disease Bechet’s syndrome Meningitis Thalamic arteriovenous malformation Transient finding in infants

  10. Clinical Features of Torsional Nystagmus Torsional jerk nystagmus (minimal vertical or horizontal components) present with eye close to central position. Slow phases may have linear-, increasing-, or decreasing-velocity waveforms Poorly suppressed by visual fixation of a distant target Exacerbated by changes in head position or vigorous head shaking Leigh JR and Zee DS. The Neurology of Eye Movements 4th Edition. Oxford University Press, New York 2006 with permission

  11. Clinical Features of Torsional Nystagmus May be suppressed by convergence Often occurs in association with ocular tilt reaction or unilateral internuclear ophthalmoplegia May be precipitated or modulated by vertical smooth pursuit movements. Leigh JR and Zee DS. The Neurology of Eye Movements 4th Edition. Oxford University Press, New York 2006 with permission

  12. Etiology of Torsional Nystagmus Syringobulbia, with or without syringomyelia Arnold-Chiari malformation Brainstem stroke (e.g., Wallenberg’s syndrome) Arteriovenous malformation in the brainstem or middle cerebellar peduncle *Often occurs in association with the ocular tilt reaction and unilateral internuclear ophthalmoplegia. Leigh JR and Zee DS. The Neurology of Eye Movements 4th Edition. Oxford University Press, New York 2006 with permission

  13. Etiology of Torsional Nystagmus Brainstem tumor Multiple sclerosis Oculopalatal tremor (“myoclonus”) Head trauma Congenital

  14. References The Neurology of Eye Movements, 4th Edition, Oxford University Press, New York, 2006. Tilikete C. Koene A. Nighoghossian N, Vighetto A, Pelisson. Saccadic lateropulsion in Wallenberg syndrome: a window to access cerebellar control of saccades? Exp Brain Res 2006;174(3):555-565.

  15. Tilikete C, Hermier M, Pelisson D, Vighetto A. Saccadic lateropulsion and upbeat nystagmus: disorders of caudal medulla. Ann Neurol. 2002 Nov;52(5):658-62.

  16. http://library.med.utah.edu/NOVEL

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