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Is anxiety a risk factor for dementia?

Is anxiety a risk factor for dementia?. John Gallacher Tony Bayer Mark Fish Yoav Ben-Shlomo Frank Dunstan. Active ageing research group: www.activeageing.co.uk. CaPS: Methods. Total cohort 2,959 men aged 45-59 at recruitment Measures at C2 (2 nd examination: C1 + 5 years)

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Is anxiety a risk factor for dementia?

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  1. Is anxiety a risk factor for dementia? John Gallacher Tony Bayer Mark Fish Yoav Ben-Shlomo Frank Dunstan Active ageing research group: www.activeageing.co.uk

  2. CaPS: Methods Total cohort • 2,959 men aged 45-59 at recruitment Measures at C2 (2nd examination: C1 + 5 years) • Trait anxiety (STAI) • Vascular risk factors • CHD • Demographics Measures at C3 (C2 + 5 years) • NART (pre-morbid cognitive function) Measures at C5 (C2 + 17 years: men aged 67-81 years) • Cognitive impairment: CIND, Dementia

  3. Statistical analysis • Logistic regression • Outcomes: • Overall impairment (CIND + Dementia) • CIND • Dementia • Adjustment for covariates: • age, sbp, cholesterol, alcohol consumption • social class, marital status, smoking, diabetes, leisure activity • Adjustment for pre-morbid cognitive function • NART at C3

  4. Available data: Sample size main analysismen with complete covariate data

  5. Available data: Sample size 20 analysismen with complete covariate data and no evidence of decline at baseline

  6. Distribution of Trait Anxiety

  7. Anxiety and cognitive impairment 31st-95th centile in 982 men with complete data

  8. Anxiety and all cognitive impairment 31st-95th centile in 755 men with complete data

  9. Anxiety and CIND 31st-95th centile in 755 men with complete data

  10. Anxiety and Dementia 31st-95th centile in 755 men with complete data

  11. Anxiety and cognitive impairment 31st-95th centile in 755 men with complete data and no evidence of decline at baseline

  12. Conclusion Anxiety is associated with cognitive impairment • Duration of follow-up (17 yrs) suggests causal association • Insidious nature of cognitive decline means reverse causality cannot be ruled out • No control for depression: association may not be independent • Analyses for dementia likely to be conservative due to survivor effect • Some evidence that effect is stronger for non-vascular dementia

  13. Further work: “Age well, feel good” Pilot Study: • October 2008-March 2009 • 3,000 older persons: 60+ years • 15,000 mailed invitations • Web links from interest groups • Remote • Recruitment (web) • Consent (web) • Assessment (web) • Bio-sampling (mail) • Follow-up (record linkage)

  14. www.activeageing.co.uk

  15. Anxiety and all cognitive impairment 31st-95th centile in 755 men with complete data and no evidence of decline at baseline

  16. Anxiety and CIND 31st-95th centile in 755 men with complete data and no evidence of decline at baseline

  17. Anxiety and dementia 31st-95th centile in 755 men with complete data and no evidence of decline at baseline

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