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CTOS 12th Annual Meeting Venice, 2-4 November 2006 Myxoid/RC Liposarcoma: Prognostic Factors And Survival. Marco Fiore marco.fiore@istitutotumori.mi.it. Soft Tissue Sarcoma INT 1980-2005. 23%. N° pz. operated 3026 Liposarcoma 685 MFH/Pleomorphic sarcoma 389
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CTOS 12th Annual Meeting Venice, 2-4 November 2006 Myxoid/RC Liposarcoma: Prognostic Factors And Survival Marco Fiore marco.fiore@istitutotumori.mi.it
Soft Tissue SarcomaINT 1980-2005 23% N° pz. operated 3026 Liposarcoma 685 MFH/Pleomorphic sarcoma 389 Leiomiosarcoma 372 DFSP 260 Aggressive Fibromatosis 240 Synovial Sarcoma 224 MPNST 222 Sarcoma NOS 143 Others 491
685 Liposarcoma INT 1980-2005 WD Liposarcoma 233 Dediff Liposarcoma 123 Myxoid Liposarcoma 202 Round cell Liposarcoma 66 Pleomorphic Liposarcoma 61 48%
myxoid FUS/TLS-CHOP t(12;16)(q13;p11) (95%) FUS/TLS CHOP/DDIT3 round cell EWS EWS-CHOP t(12;22)(q13;q12) (5%) pleomorphic
329 Myxoid/RC Liposarcoma INT 1980-2005 Median Age 49 yrs Male : Female 1 : 1 Median Size 8.5 cm Deep Site 84% Grade (FNCLCC) I 54% II 23% III 22%
Size… STS high grade DFS <2,5 2,5-5 5-10 10-15 15-20 >20 cm Suit HD. J Clin Oncol 1988; 6: 854
Grading… OS grade 1 grade 2 grade 3
Round cell component… RC >5% Antonescu CR, Clin Cancer Res 2001;7:3977
Pattern of Distant Mets 41% extra-pulmonary mets 26% lung mets 33% both 74% of metastatic patients had at least one extra-pulmonary mets
43% 49% 33%
LR Intralesional 100% Marginal 60-80% Wide 10-30% Radical < 5% Enzinger and Weiss’sSOFT TISSUE TUMORS - 2001
Prognosis of myxoid/round cell liposarcoma is relatively good, if compared with other STS • Cut-off of 5% of RC component single out a group tumor with 81% 10-yrs DSS, which is actually in the range of intermediate grade STS • As expected, phase at presentation, tumor size and grade,and surgical margins are independent prognostic factors for survival • Pattern of metastases can affect survival