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Change in longest diameter = -19%

Change in longest diameter = -19%. Change in sum of perpendicular diameters = -21%. Change in CT Volume = -37%. Change in PET SUVmax = -18%. Comparison of Response Measures. Change in longest diameter = -19% Change in sum of perpendicular diameters = -21% Change in CT Volume = -37%

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Change in longest diameter = -19%

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  1. Change in longest diameter = -19%

  2. Change in sum of perpendicular diameters = -21%

  3. Change in CT Volume = -37%

  4. Change in PET SUVmax = -18%

  5. Comparison of Response Measures • Change in longest diameter = -19% • Change in sum of perpendicular diameters = -21% • Change in CT Volume = -37% • Change in PET SUVmax = -18%

  6. Standardized Uptake Value SUV (time) = Radioactive Concentration x Weight Injected Activity • Under certain circumstances, 18FDG SUV correlates with metabolic rate of glucose and/or the number of viable tumor cells • Simplified semi-quantitative measure that can be routinely performed in clinical PET studies • Adjusts for differences in patient size and injected activity

  7. EORTC PET metabolic response criteria • Complete response (CR): Complete resolution of all lesions • Partial Response (PR): Greater than or equal to 25% decrease in SUVmax. • Stable Disease (SD): Less than 25% change • Progressive Disease (PD): Greater than or equal to 25% increase in SUVmax

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