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Economic Implications of Nanobiotechnology Rudy Juliano Professor of Pharmacology &

Economic Implications of Nanobiotechnology Rudy Juliano Professor of Pharmacology & Principal Investigator Carolina Center for Cancer Nanotechnology Excellence. What is Nanobiotechnology? Examples of Nanobiotechnology Research at UNC (Carolina Center for Cancer Nanotechnology

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Economic Implications of Nanobiotechnology Rudy Juliano Professor of Pharmacology &

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  1. Economic Implications of Nanobiotechnology Rudy Juliano Professor of Pharmacology & Principal Investigator Carolina Center for Cancer Nanotechnology Excellence

  2. What is Nanobiotechnology? • Examples of Nanobiotechnology Research at UNC (Carolina Center for Cancer Nanotechnology Excellence, C-CCNE) 3. Potential Economic Impact of Nanobiotechnology

  3. The Nanosize Range: About 10-100 Nanometers A nanometer = 1 billionth of a meter

  4. Why Nanotechnology? The physical properties of materials on the nano-scale often differ from bulk properties (conductivity, optical properties, chemical reactivity, other properties) This means new opportunities in materials science and device fabrication Predicted $1 Trillion market for nanotech products within 10 years

  5. Why Nanobiotechnology? Human cells function as assemblages of multi-protein nanomachines (ribosomes, proteosomes, mitochondria, signalosomes, focal contacts) Nanotechnology lets us intervene in cellular events on the cell’s own size scale Multiple potential applications to diagnosis, Imaging, therapy

  6. Carolina Center of Cancer Nanotechnology Excellence

  7. Centers of Cancer Nanotechnology Excellence University of North Carolina Harvard-MIT Northwestern Emory-Georgia Tech Washington University CalTech-UCLA University of California San Diego Stanford

  8. CAROLINA CENTER OF CANCER NANOTECHNOLOGY EXCELLENCE

  9. A Leading Technology Focus of the C-CCNE CTP

  10. Project 1: PI: J. DeSimone UNC Chemistry

  11. Mold Fabrication SLS = SLS > Silicon Master Spreading Coefficient 0 PFPE will spread Perfluoropolyether mould

  12. Curing process UV curing under pressure Preparation for curing

  13. PRINT Particles Can Be Made of Virtually Any Size, Shape, or Composition and can Incorporate Drugs or Imaging Agents

  14. Project 3: PI: O. Zhou UNC Physics Carbon Nanotube X-Ray for in-vivo Cancer Detection and Treatment • 1. Development of novel pixilated x-ray sources that can generate spatially and temporally modulated x-ray beams • for high-speed tomographic cancer imaging and treatment. • 2. Establishment of Multiplexing X-Ray Radiography. • 3. Design and testing of a high-speed micro-CT scanner for dynamic CT imaging of small animals. • 4. Stationary x-ray system for human breast tomosynthesis. • 5. Design, simulation, and construction of a prototype MBFEX source for the micro-RT unit that can deliver • highly conformal and high dose radiation. • 6. Utilizing the new technologies to study lung and colon cancers in animal models.

  15. CNT X-Ray of Living Mouse with Respiratory Gating

  16. TEM images of 4 nm, 8 nm, 12 nm, 16 nm and 22 nm iron oxide nanocrystals. A view of the magnetic force setup in the Superfine lab. Project 4: PI: Wenbin Lin UNC Chemistry Aim (1) development of magnetic nanoparticles with desirable surface characteristics based on novel chemistries Aim (2) refinement of technologies to manipulate and image magnetic nanoparticles in vivo Aim (3) evaluation of the utility of the magnetic nanoparticle platform in targeted delivery of multi-modality imaging contrast agents and therapeutic formulations to brain tumors of a mouse model.

  17. Fabrication of Gadolinium-containing Nanoparticles for MR Image Enhancement 200 nm 100nm

  18. Enhanced MR Imaging of a Mouse Brain Tumor Using Gadolinium-containing Nanoparticles

  19. Nanotechnology Economic Impacts in Academia Source: NCBC

  20. Nanobiotechnology Economic Impacts in Industry Source: NCBC

  21. Nanobiotechnology Economic Impacts in Industry Application Possible Partners Drug Delivery Big Pharma (GSK*, Pfizer etc) Imaging Instrument makers (GE, Siemens*) Diagnostics Clinical lab suppliers (BD, Agilent)

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