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Development of BioProducts for Animal and Human Health

Development of BioProducts for Animal and Human Health. J. J. Lin, Ph.D. CEO/Chief Scientist Imagilin Technology, LLC. Imagilin Technology, LLC. Who Are We:. Biotechnology company, Frederick, Maryland Technology platforms of probiotics as biomedicines

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Development of BioProducts for Animal and Human Health

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  1. Development of BioProducts for Animal and Human Health J. J. Lin, Ph.D. CEO/Chief Scientist Imagilin Technology, LLC Imagilin Technology, LLC

  2. Who Are We: • Biotechnology company, Frederick, Maryland • Technology platforms of probiotics as biomedicines • Innovative probiotic products

  3. Emerging of Antibiotics Resistance Bacteria-Superbugs January 16, 2006, The Washington Post

  4. Definition of Probiotics • The Food and Agricultural Organization of the United Nations (FAO): • "live microorganisms administered in adequate amounts which confer a beneficial health effect on the host.“

  5. Market Size of Animals • Farm Animals • - USA, US $79.9 Billions Meat production • Pet Foods • -USA, 15.7 Billions • Pet Nutrition Supplements • -US $1.00 billion, 17-22 % growth rate

  6. Innovative Technology • Novel strains selection systems: • -In vitro and in vivo selection of strains with enhanced immune responses. • Microencapsulation of probiotics: • - preservation of probiotics under harsh environment • Probiotics as biomedicine: • -against infectious diseases related to digestive disorders

  7. Effects of different pH on growth of P. acidilactici and L. acidophilus in vitro Pediococcus acididlactici Lactobacillus acidophilus pH 6.2 pH 2.0 pH 1.5

  8. Poultry Coccidiosis E. tenella E. acervulina E. maxima E. tenella

  9. No toxic effects of P. acidilactici on broilers infected by Eimeria acervulii

  10. Effects of P. acidilactici on broilersinfected by Eimeriaacervulii Effects of Pediococcus acidilactici on broiler chickens* infected with Eimeria acervulii. USDA, ARS, Beltsville, MD (X 108 Oocysts) (gm) *: 20 chickens per group; chickens were orally infected with 5,000 sporulated oocytes and fed with or without P. acidilactici (P.a.).

  11. Effects ofserologicalresponses of P. acidilactici on broilersinefected by Eimeria Spp.

  12. Product Lines • Nutraceutical Products: • - MITOMAXR : Premium Probiotics for Dogs, • Cats, Small animals • - MITOBIRDTM : Premium Probiotics for Birds • - MITOFISHTM: Premium Probiotics for Fish • - MITOBOOSTTM : Natural Antioxidant and • Immune Enhancers for Pets • Farm Animal Feeds Additives: • -MITOGROWTM: Premium probiotics for Poultry • -MITOSWINETM: Premium probiotics for Pigs

  13. Summary • Two scientific publications in peer review journals • Lead to develop the probiotic product lines to • pet and farm animal business • Develop international business partnerships in • Japan, China, Hong Kong, Taiwan, and Brazil

  14. Effects of different temperature on growth of P. acidilactici and E. faecium in vitro P. acidilactici E. faecium 37C 65C* * Treated bacteria at 65C for 3 hrs, plated onto MRS plate ,and incubated at 37C overnight

  15. Characteristics of P. acidilactici • Natural existence in animals and humans • Generally Recognized As Safe (GRAS) by FDA • Enhanced immune responses • Less sensitive to exposure of oxygen than • Lactobacillus and Bifidobacterium. • More resistant to heat than • Lactobacillus and Bifidobacterium. • More resistant to acidic environment

  16. Trends • Emerging Antibiotics resistant SuperBugs • -Abandon Antibiotics • -Alternative Medicines • Demanding Nutracetutical products • -Healthy food • -Nutrition supplement • -Therapeutical effects • Requiring Green (organic) foods • -Antibiotics free • -Growth hormone free • -Pesticide free

  17. Performance of chicks(Cobb) fed or not with probiotic or growth promoter during all the breeding period (1 to 42 days of age) Brazil, Sao Paulo Means followed by different letters in the column are different among themselves by the Tukey test (p<0,05), 40 birds per treatment PEI: Viability X Weight gain/ convertion rate X 10.

  18. Effect of Levofloxacin the growth of Pediococcus acidilactici Control 50 ug/ml 4 hours 200 ug/ml 100 ug/ml Mixed 300 mg P. acidilactici with 3 ml of MRS medium, added 50 ug/ml, 100 ug/ml, 200 ug/ml of levofloxacin, followed by incubating at 37 C for two nights, and plated 100 ul at 10,000 dilution onto MRS plate. The colony formation was obtained after incubated overnight at 37C

  19. Poultry Coccidiosis

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