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Clinical failure and its management

Clinical failure and its management. David W. Denning Director, National Aspergillosis Centre University Hospital South Manchester [Wythenshawe Hospital] The University of Manchester. Problems with antifungal therapy. Drug toxicity Drug interactions and low blood levels. Drug toxicities

606 views • 48 slides

Clinical failure and its management

Clinical failure and its management. David W. Denning Director, National Aspergillosis Centre University Hospital South Manchester [Wythenshawe Hospital] The University of Manchester. Problems with antifungal therapy. Drug toxicity Drug interactions and low blood levels. Drug toxicities

623 views • 48 slides

Clinical failure and its management

Clinical failure and its management. David W. Denning Director, National Aspergillosis Centre University Hospital South Manchester [Wythenshawe Hospital] The University of Manchester. Problems with antifungal therapy. Drug toxicity Drug interactions and low blood levels. Drug toxicities

500 views • 48 slides

Deconstruction of Drop Volume Ratio/Temperature Optimization Experiments

Deconstruction of Drop Volume Ratio/Temperature Optimization Experiments. Joseph R. Luft, Edward H. Snell, Jennifer R. Wolfley, Meriem I. Said, Ann M. Wojtaszcayk, Raymond M. Nagel, Angela M. Lauricella, Steven A. Potter, Max H. Thayer, Christina K. Veatch,

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Date: 2008/07/01

Large aggregate species in conjugated polymer solutions characterized by dynamic light scattering and in situ rheological/flow turbidity measurements Chih J. Lin 1 , Chan Y. Kuo 1 , Chi C. Hua 1, * Show A. Chen 2

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Mild intermittent asthma

Asthma is a condition characterized by paroxysmal narrowing of the bronchial airways due to inflammation of the bronchi and contraction of the bronchial smooth muscle. The inflammatory component is central to the pathogenesis of symptoms: dyspnea , cough, and wheezing.

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Development and validation of a stability indicating RP-HPLC method for simultaneous determination of Lamivudine and Sta

A simple, rapid, precise, and accurate stability-indicating, reversed phase (RP) HPLC assay method was developed and validated for simultaneous estimation of Lamivudine (3TC) and Stavudine (d4T) in bulk drugs and commercial tablets. The method has shown adequate separation of 3TC and d4T from their degradation products. Separation was achieved on a Kromasil C8 (250mm×4.6mm i.d; 5 µm) column at a detection wavelength of 265nm, using a mobile phase consisting of acetonitrile–0.02M ammonium acetate buffer (pH 4.5) in a gradient elution mode at a flow rate of 1 ml/min. The retention times for lamivudine and stavudine were found to be 13.66 and 16.51 min respectively Lamivudine (3TC), stavudine (d4T) and their combination drug product were subjected to acid, base and neutral hydrolysis, oxidation, thermal and photolytic stress conditions and the stressed samples were analyzed by the proposed method. Validation of the method was carried out as per ICH guidelines. Quantitation was achieved with UV detection at 265 nm based on peak area with linear calibration curves at concentration ranges 2.5-50µg/ml for 3TC and 0.5-10µg/ml for d4T (R2 > 0.9999 for both drugs). The limits of detection were 0.82 µg/ml and 0.33 µg/ml for lamivudine and stavudine, respectively. The method was found to be specific and stability indicating as no interfering peaks of degradants and excipients were observed. The proposed method is hence suitable for application in quality-control laboratories for quantitative analysis of both the drugs individually and in combination dosage forms, since it is simple and rapid with good accuracy and precision

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Analysis of phytochemicals, minerals and in vitro antioxidant activities of Gongronema latifolium leaves

Gongronema latifolium is primarily used as spice and vegetable as well as a herb in traditional medicine in the treatment of malaria, diabetes and hypertension. This study is aimed at providing in vitro laboratory knowledge on Gongronema latifolium leaves.Methods: Minerals were analyzed using Atomic Absorption Spectrophotometer while phyto-nutrients were screened using standard laboratory procedures. 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging and reducing power activities were determined spectrophotometrically. Usunobun Usunomena | Igwe V. Chinwe"Analysis of phytochemicals, minerals and in vitro antioxidant activities of Gongronema latifolium leaves" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-4 , June 2017, URL: http://www.ijtsrd.com/papers/ijtsrd87.pdf http://www.ijtsrd.com/biological-science/biotechnology/87/analysis-of-phytochemicals-minerals-and-in-vitro-antioxidant-activities-of-gongronema-latifolium-leaves/usunobun-usunomena

72 views • 5 slides