'Abc transporters' diaporamas de présentation

P-GLYCOPROTEIN AND DRUG TRANSPORT

P-GLYCOPROTEIN AND DRUG TRANSPORT. Michael M. Gottesman Chief, Laboratory of Cell Biology, NCI Deputy Director for Intramural Research National Institutes of Health. January 18, 2007. Estimated New Cancer Cases & Deaths, 2005. ** Vast majority of deaths due to chemotherapy resistance.

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Biophysical dissection of ABC Transporter mechanism

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Chapter 8 Transporters and Active Membrane Transport Principles of Membrane Transport

Chapter 8 Transporters and Active Membrane Transport Principles of Membrane Transport. Relative Permeability of a Synthetic Lipid Bilayer to Different Classes of Molecules

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CYORF is a web-based resource that facilitates annotation of multiple genomes by a scientific community. The annotation is open to the public, but only registered members of the community may alter the database.

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Nebojsa Mirkovic, Carles Ferrer-Costa, Marc A. Marti-Renom, Alvaro N.A. Monteiro, Andrej Sali

Functional Consequences of the SNPs : BRCA1, Membrane Transporters and More. Nebojsa Mirkovic, Carles Ferrer-Costa, Marc A. Marti-Renom, Alvaro N.A. Monteiro, Andrej Sali. Single Nucleotide Polymorphisms (SNPs).

416 views • 22 slides

PASSAGE OF DRUGS ACROSS MEMBRANES

PASSAGE OF DRUGS ACROSS MEMBRANES. A drug must cross one or more biologic membranes to reach its site of action (absorption later distribution, interaction with the receptor and finally elimination).

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Growth and differentiation

Growth and differentiation. Figure 4.2. Figure 4.3. Figure 4-6 Facilitated diffusion. Figure 4-7 Coupled transport. Figure 4-8 ABC transporters. Figure 4-9 Siderophores and iron transport. Figure 4-10 Group translocation: the phosphotransferase system (PTS) of E. coli.

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V10 Pharmacogenomics of P-Glycoprotein

V10 Pharmacogenomics of P-Glycoprotein. Review of lecture V9 .. Paper on Pharmagenomics of PGP. Drug resistance of cells. There are three major mechanisms of drug resistance in cells:

392 views • 18 slides

Physical insulation of pathways or functions

Physical insulation of pathways or functions. How to build complex synthetic circuits?. Electronic hard wired: reusability of components. Biology is diffusive: crosstalk We need to find a way to insulate the different components circuits. Pathway insulation methods.

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Protection of Secreted Proteins in Cyanobacteria

Protection of Secreted Proteins in Cyanobacteria. Aaron Holman. How do cells secrete proteins?. Signal sequence. Most use Sec pathway. Some use TAT pathway. Why?. Harsh conditions inhibit folding. Archae, Bacteria (Cyanobacteria). Goals. How do cyanobacteria protect secreted proteins?

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ABC-ATPases as Regulatory Transporters for NHRs:

ABC-ATPases as Regulatory Transporters for NHRs: Chemical sensors for endogenous metabolites and xenobiotics. SIGMA-ALDRICH. ABC-ATPases as Regulatory Transporters for NHRs: chemical sensors for endogenous metabolites and xenobiotics

107 views • 2 slides