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Quality evaluation of acetaminophen formulations manufactured in Congo DR

Quality evaluation of acetaminophen formulations manufactured in Congo DR

The objective of this work was to study the accelerated stability of Acetaminophen 500mg tablet sold on the Congolese market. Five specialties of Acetaminophen were examined: four locally manufactured generics and the innovator. Two analytical tests were made to study the change during the storage: The dosage of active ingredient by HPLC and dissolution profile by UV / Visible spectrophotometer. The results of this study reveal a problem with the manufacturing processes of Congolese generics. That is caused because they all present an abnormal drop of active ingredient and a release below the limit, from the sixth month of storage at a temperature and relative humidity of 40 °C and 75%.HR as per ICH guidelines.

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106 views • 7 slides
Accelerated Shelf Life Study of Fish Oil Stored in Medicinal Plant Extracts

Accelerated Shelf Life Study of Fish Oil Stored in Medicinal Plant Extracts

Stability studies provide evidence on in what way the quality of a drug or its product varies with time under influence of changing environmental factors such as humidity, temperature and light. Present study is an attempt to study accelerated stability of fish oil incorporated with three medicinal plant extracts, which can be used for preserving it from further oxidation. The results of accelerated shelf life studies of fish oil treated with O. sanctum extracts (2 mg %). It is found that E.coli, Salmonella and P. aeruginosa were absent throughout the storage period of 6 months in the treated sample. Though TPC was found high at initial stage (1250000 cfu/gm.), by 6 months the value was reduced to

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61 views • 6 slides

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