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Computational Systems Biology

Computational Systems Biology

Computational Systems Biology. Prepared by: Rhia Trogo Rafael Cabredo Levi Jones Monteverde. What are Biological Systems?. Popular Notion: It is a complex system consisting of very many simple and identical elements interacting to produce what appears to be complex behavior

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Chromosomally unstable mouse tumors have genomic alterations similar to diverse human cancers

Chromosomally unstable mouse tumors have genomic alterations similar to diverse human cancers

Chromosomally unstable mouse tumors have genomic alterations similar to diverse human cancers. Journal Club 14.09.2007. Introduction.

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Curcumin Induces both Apoptosis and Autophagy in Human Papillary Thyroid Carcinoma BCPAP Cells

Curcumin Induces both Apoptosis and Autophagy in Human Papillary Thyroid Carcinoma BCPAP Cells

10 th AOTA Congress BALI, INDONESIA, 2012. Curcumin Induces both Apoptosis and Autophagy in Human Papillary Thyroid Carcinoma BCPAP Cells. Zhang Li Jiangsu Institute of Nuclear Medicine Wuxi, Jiangsu, China Contact: zhangli@jsinm.org. ?. Curcumin. Thyroid cancer. Curcumin.

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Developing Strategy for Next Generation of Antibody - Drug Conjugates

Developing Strategy for Next Generation of Antibody - Drug Conjugates

Comprised of a recombination monoclonal antibody and cytotoxic payloads through a linker, antibody drug conjugate (ADC) not only has highly cytotoxic antitumor effect of small molecule drugs, but also combines the high selectivity, stability and favorable pharmacokinetic characteristics of mAb.

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Akt inhibitor

Akt inhibitor

Also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds. Ipatasertib shows a powerful inhibition of all protein kinase B (Akt) isoforms but a weak suppression towards other members of the protein kinase family.

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akt pathway

akt pathway

PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Key proteins involved are phosphatidylinositol 3-kinase (PI3K) and Akt/Protein Kinase B.

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