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Summary of Existing Problems in CART Therapy

Summary of Existing Problems in CART Therapy

To be sure, the CD19-CART cell therapy technology should be individualized, but in addition to the CAR T design itself that will affect the treatment effect, the timing of application, the patient's basic condition, the dose of infusion, etc., will have a significant impact on the clinical effect. Different car gene vectors affect CART cell function, and currently used vectors are gamma retroviruses, lentiviruses, and car t plasmid. Even if the CAR structure is the same, the CART cells cultured by different research centers will be very different. In the composition of the new generation of CAR, a co-stimulation region was added, and in particular, the addition of CD28 or CD137 in the costimulatory region resulted in the proliferation of cells in vivo and the anti-tumor activity was significantly enhanced.

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150 views • 13 slides
Anti-lymphocyte Tumor Mechanism of CD19-CART Cells

Anti-lymphocyte Tumor Mechanism of CD19-CART Cells

Lymphoid malignancies include lymphocytic leukemia and lymphoma, which are tumors that occur on lymphocytes such as B cells, T cells, and NK cells. At present, there are many difficulties in its treatment, which are related to the recurrence and refractory of the diseases in the clinic. In the past 10 years, great progress has been made in the clinical treatment of lymphatic system tumors. Anti-CD20 monoclonal antibodies have been widely used in CD20-positive B-cell non-Hodgkin's lymphomas, and have achieved good results, becoming the first-line clinical application. However, since the cell surface of lymphoma and acute-chronic lymphocytic leukemia often has only CD19 antigen, an anti-CD20 antibody such as rituximab has no obvious therapeutic effect on it, therefore there is an urgent need for a new treatment method to improve the cure rate of lymphoma and acute and chronic lymphoma.

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The Clinical Application of CD19-CART Cells

The Clinical Application of CD19-CART Cells

The study of CD19 CART cells is currently a hot spot for B-cell lymphomas. In 2010, Kochenderfer et al. first reported the role of CD19-CART cells in the treatment of relapsed and refractory follicular lymphoma. In 2012, Kochenderfer et al. reported that 8 patients with relapsed and refractory B-cell lymphoma received CART cell therapy, including 4 CLL, 3 follicular neoplasms, and 1 splenic marginal B-cell lymphoma.

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95 views • 7 slides

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