'Cyclin d1' diaporamas de présentation

Lymphoma and Multiple Myeloma

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Advances in Biology and Pathophysiology of Multiple Myeloma

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Chapt. 16 Eukaryotic Cell cycle; Chapt. 17 Stem cells

Chapt. 16 Eukaryotic Cell cycle; Chapt. 17 Stem cells. Chapt. 16 Student learning outcomes : Explain basic phases of eukaryotic cell cycle Regulators, checkpoints Describe events of mitosis Regulation by MPF, phosphorylation, proteolysis Explain regulators of progression:

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Text Learning and Information Extraction

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Nuclear receptors

Nuclear receptors. Reshma Taneja Department of Molecular, Cell and Developmental Biology Mount Sinai School of Medicine Advanced Signal Transduction Course/ STKE March 31st, 2005. Nuclear Receptors. Introduction -Types -Domain Structure -DNA binding specificities

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HEREDITARY BREAST CANCER IN DEVELOPING COUNTRIES

HEREDITARY BREAST CANCER IN DEVELOPING COUNTRIES. Richard G. Pestell, MD, PhD Kimmel Cancer Center Jefferson University Hospital. Major Genetic Defects in Breast Cancer. Major Genetic Defects in Breast Cancer. Sex Hormone Regulation of Growth Factor Systems in Breast Cancer.

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Case 5

Case 5. M, 78 ys Violaceous plaque on the penis History of nodal Mantle Cell Lymphoma (courtesy Prof. A. Maiorana). CD20. CD3. CD5. Bcl-6. Cyclin-D1. Mib-1. DIAGNOSIS. Cutaneous localization of Mantle Cell Lymphoma FISH: presence of t(11;14)(q13;q32). t(11;14)(q13;q32).

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0.1

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Control siRNA BRG1 siRNA

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Ctrl siRNA

Supplemental Figure 3. A. B. Ctrl siRNA. PIK3R3 siRNA. Ctrl siRNA + - PIK3R3 siRNA - +. p-RB (ser 780). Cyclin D1. p-AKT (ser 473). p- mTOR (ser 2448). PIK3R3. actin.

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Supplemental Figure 1

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Mitochondrial membrane depolarization

? -sitosterol. Skin cancer. Lung cancer. Breast cancer. - + +++. Efficacy. CDKI: p21 & p27. Bax /Bcl-2. Mitochondrial membrane depolarization. Cyclin D1. CDK-4. Apoptosis. G0/G1 Arrest.

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Cyclin A

P95 SC-2. P95 SC-2. P43 SC-2. P43 SC-2. Immortal DF-1. Immortal DF-1. P6 CEF. P6 CEF. P18 CEF. P18 CEF. c. Cyclin A. Cyclin D1. e. a,b. a. a. b. d. b. c. d. Cyclin B2. c. Cyclin D2. a. b. a. c. c. c. b. b. d. c. Cyclin B3. a. Cyclin E. b. a. a. b. b. d.

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