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Nicotine causes dose-dependent release of DA in the striatum

1 cigarette contains ~1mg nicotine which results in a ~ 0.014mg/kg dose to a 70kg human. Nicotine causes dose-dependent release of DA in the striatum. 0.025mg/kg. 0.050mg/kg. Dose-dependent IV nicotine-induced DA release in the rat nucleus accumbens (Pontiere et al, 1996). 1.

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Dorsal caudate - PowerPoint PPT Presentation

Nicotine causes dose-dependent release of DA in the striatum