'Er stress' diaporamas de présentation

Non alcoholic fatty liver disease (NAFLD) Diagnosis and evaluation

Non alcoholic fatty liver disease (NAFLD) Diagnosis and evaluation. Raika Jamali M.D. Gastroenterologist and hepatologist Tehran University of Medical Sciences. Epidemiology.

3.77k views • 219 slides

Apoptosis and Diseases

Apoptosis and Diseases. Concept Apoptotic process and changes Key molecules and Major pathways Techniques to detect apoptosis Apoptosis-related diseases Insufficient apoptosis in diseases Excessive apoptosis in diseases Coexistence of insufficient and excessive apoptosis in diseases

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The Endoplasmic Reticulum: an emerging player in redox pathophysiology

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Biomarkers of Exposure to Hazardous Substances (2017-2022)

Biomarkers of Exposure to Hazardous Substances (2017-2022). The UC Davis Superfund Research Center conducts research to: Improve understanding of the mechanisms by which hazardous chemicals produce adverse health affects,

313 views • 31 slides

Dr. R.A.SIDDIQUE M.V.Sc., PhD Scholar National Dairy Research Institute, Karnal, Haryana, 132001

THE ASK1-MAP KINASE CASCADES IN MAMMALIAN STRESS RESPONSE. Dr. R.A.SIDDIQUE M.V.Sc., PhD Scholar National Dairy Research Institute, Karnal, Haryana, 132001 INDIA E-mail: riazndri@gmail.com. STRESS:

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J12. The Pathophysiological Mechanisms for Triggering Detrusor Overactivity in Chronic Ischemic Urinary Bladder. ??? 1 , ??? 2 , ??? 1 1 ??????? 2 ???????. Introduction.

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Regolazione della traduzione

Regolazione della traduzione. generale specifica. Initiation Factor Activity eIF-1 Fidelity of AUG codon recognition eIF-1A Facilitate Met-tRNAiMet binding to small subunit eIF-2 Ternary complex formation eIF-2B (GEF) GTP/GDP exchange during eIF-2 recycling

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Kacy Gillette 3/17/14

Endoplasmic Reticulum. Kacy Gillette 3/17/14. Endoplasmic Reticulum (ER). Was discovered in 1945 by Albert Claude in Belgium. Eukaryotic organelle that forms an interconnected network of tubules, vesicles and cisternae within cells.

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eIF2 a kinase. 40S. a. tRNA Met. tRNA Met. tRNA Met. tRNA Met. tRNA Met. b. 40S. g. PO 3. 40S. 40S. 40S. 40S. GTP. GTP. GDP. GTP. GTP. GTP. GTP. 60S. 60S. Translation initiation factor eIF2: Initiation and Recycling.

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Nicardipine induces apoptosis via IRE1 activation in the PC12 cells

Although an endoplasmic reticulum (ER) induction by calcium-channel blocker has been reported, the mechanism of ER stress-mediated apoptosis by nicardipine is unknown. Here, we demonstrated induction of apoptosis by nicardipine in PC12 cells. It was accompanied by the formation of apoptotic bodies via activation of ER-stress sensor, inositol-requiring enzyme 1 (IRE1). IRE1 induces the downregulation of key anti-apoptotic Bcl-2 expression in apoptosis. However, the altered expression of ER chaperones was not observed following nicardipine treatment. The results suggest that insight into the molecular mechanisms underlying nicardipineinduced apoptosis may facilitate the reduction of side effects and active treatment.

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Ligand

EXTRINSIC PATHWAY. INTRINSIC PATHWAY. Ligand. UV, radiation, chemo, hypoxia. ER Stress (misfolded proteins). Death receptor. Plasma Membrane. Adapter. Procaspase-12. Initiator Caspase-8. Mitochondria. Initiator Caspase-12. Bcl-2/ Bcl-x L. Bid. Ca ++. TRAF2. IP3R. Ca ++. Cyto c.

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Confirmed Speakers Conference:

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Center for Integrated Animal Genomics

Research Experience in Molecular Biotechnology & Genomics Summer 2010 Plant Science Institute. Center for Integrated Animal Genomics. Autophagy is associated with ER stress in Arabidopsis thaliana. Junmarie Soto 1,2 , Yimo Liu 1,3 and Diane C. Bassham 1,3

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Role of Endoplasmic Reticulum Stress in Mechanism of Action of Antitumor Quinols.

PMX 8098. Gene expression changes (>2) in HCT116 cells in response to PMX 290. ER Tracker. 4 3 2 1 0 -1 -2 -3 -4. Change in expression (LOG2). Merge. DDIT3 TRIB3 ASNS C20orf139 UPP1 DNAJB9 FGF19 DDIT4 SQSTM1 ATF3 GDF15 BIRC3 SLC7A11 MAP1LC3 PRO618 PPP1R15A KIAA1718

443 views • 1 slides