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Analysis of whole genome association studies in pedigreed populations

Analysis of whole genome association studies in pedigreed populations

Analysis of whole genome association studies in pedigreed populations. Goutam Sahana Genetics and Biotechnology Faculty of Agricultural Sciences Aarhus University, 8830 Tjele, Denmark. Concept of mapping. Identification of genetic variant underlying disease susceptibility or a trait value.

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804 views • 59 slides
WHY?

WHY?

NEW SCIENCE AND THERAPIES FOR PATIENTS WITH MENTAL ILLNESS. Now is the most promising time in the past two decades for mental health research. WHY?. PAST INVESTMENTS IN BASIC RESEARCH. Basic neuroscience. Mental illness is a biological brain disease

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558 views • 42 slides
Contemplating the End of the Beginning

Contemplating the End of the Beginning

Contemplating the End of the Beginning. Francis S. Collins, M.D., Ph.D. HGM 2003 Cancun, Mexico April 29, 2003. Characteristics of the Human Genome Sequence. 99% of euchromatin (2.85 Gb) is covered Error rate: <<1:10,000 bp <400 unclonable gaps

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415 views • 33 slides
Polymorphism

Polymorphism

Polymorphism. Haixu Tang School of Informatics. cause inherited diseases. Genome variations. underlie phenotypic differences. Restriction fragment length polymorphism (RFLP). RFLP. Haplotype. AATG. Microsattelite (short tandem repeats) polymorphysim. 7 repeats. 8 repeats.

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510 views • 30 slides
Population structure

Population structure

Population structure. Population structure in case-control studies. Population consists of underlying subpopulations. Disease prevalence different between subpopulations. Cases preferentially ascertained from specific subpopulations.

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380 views • 21 slides

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