'Inactivation' diaporamas de présentation

TYPES OF GENETIC INSTABILITY IN CANCER

TYPES OF GENETIC INSTABILITY IN CANCER. Aneuploidy Chromosome breakage Deletions and translocations Gene Amplification HSRs - homogeneously staining regions DMs - double minutes Elevation of mutation rates Epigenetic changes "CIMP" (CpG island methylator) phenotype.

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BIOELECTRICITY AND EXCITABLE TISSUE

BIOELECTRICITY AND EXCITABLE TISSUE. THE ORIGIN OF BIOELECTRICITY AND HOW NERVES WORK. D. C. Mikulecky Department of Physiology and Faculty Mentoring Program. THE RESTING CELL. HIGH POTASSIUM LOW SODIUM NA/K ATPASE PUMP RESTING POTENTIAL ABOUT 90 - 120 MV

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Glycogen Metabolism

Glycogen Metabolism. Introduction. Storage Polysaccharides. Why Polysaccharides?. Rapid mobilization Support anaerobic metabolism Animals cannot convert fats to glucose precursors. Why Polymers?. Osmotic Problem!. Glycogen Metabolism. Glycogen Breakdown. Storage Tissues.

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Two Substrate Reactions

Two Substrate Reactions. Many enzyme reactions involve two or more substrates. Though the Michaelis-Menten equation was derived from a single substrate to product reaction, it still can be used successfully for more complex reactions (by using k cat ). Random. Ordered. Ping-pong.

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Cellular Senescence What is it? What causes it? Why is it important (cancer and aging)?

Cellular Senescence What is it? What causes it? Why is it important (cancer and aging)?. Cellular Senescence What is it? Response of normal cells to potentially cancer-causing events The senescence response is an anti-cancer mechanisms that prevents

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General Properties of Cardiac Muscle

General Properties of Cardiac Muscle. Fig Heart. Fig 10-1. Fig Microscopic Structure of Cardiac Muscle. Fig 9-2. Properties of myocardial cells. Automaticity (Chronotropic property) Conductivity (Dromotropic property) Contractivity (Inotropic property) Excitability (Bathmotropic property).

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Malabsorption syndrome

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Predicting bacterial spore inactivation by novel processing technologies October, 2008

Christopher J. Doona, Florence E. Feeherry, Edward W. Ross, Kenneth Kustin DoD Combat Feeding Directorate US Army Natick RD&E Center. Predicting bacterial spore inactivation by novel processing technologies October, 2008. Introduction.

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PHOSPHOROLYSIS OF a (1-4)LINKAGES UP TO 4 GLUCOSE RESIDUES FROM AN a (1-6)BRANCH POINT

GLYCOGEN BREAKDOWN. PHOSPHORYLASE. (GLUCOSE)n + Pi (GLUCOSE)n-1 + G-1-P. PHOSPHOROLYSIS OF a (1-4)LINKAGES UP TO 4 GLUCOSE RESIDUES FROM AN a (1-6)BRANCH POINT. GLYCOGEN SYNTHESIS. HEXOKINASE. GLUCOSE + ATP GLUCOSE-6-PHOSPHATE + ADP. PHOSPHOGLUCOMUTASE.

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The Chromosomal Basis of Inheritance

The Chromosomal Basis of Inheritance. Chromosomal Theory of Inheritance. Genes are physically located at loci on chromosomes Additionally, it is chromosomes that undergo segregation and independent assortment. Thomas Hunt Morgan.

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Platform downstream processes in the age of continuous chromatography: A case study

Platform downstream processes in the age of continuous chromatography: A case study. Mark Brower BioProcess Technology & Expression Bioprocess Development Kenilworth, NJ. Integrated Continuous Biomanufacturing Castelldefels , Spain 20-24 October 2013. Transition to Future Concepts.

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Membership and Professional Standards Committee Fall 2012

Proposal to Change the OPTN/UNOS Bylaws to Better Define Notification Requirements for Periods of Functional Inactivity. Membership and Professional Standards Committee Fall 2012. The Problem. Bylaws do not clearly outline Member actions for functional inactivity, including:

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The Human Genome

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MSH2

http:// en.wikipedia.org /wiki/File:Protein_MSH2_PDB_2o8b.png. MSH2. And Its Role in Cancer. About. mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli ) Tumor suppressor 2805 base pairs 16 exons Mutations are distributed evenly across gene

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Non-coding RNAs (ncRNAs)

Non-coding RNAs (ncRNAs). Non-coding RNAs (ncRNAs). http://www.gurdon.cam.ac.uk/~miskalab/research.php. Non-coding RNAs (ncRNAs) *Small Regulatory RNAs *Infrastuctural RNAs *Micro-, Small-interfering RNAs *Long Non-coding RNAs. Mattick 2009. Review: X inactivation.

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In vitro effects of garlic compounds on human CYPs (2A6, 2E1 and 3A4)

In vitro effects of garlic compounds on human CYPs (2A6, 2E1 and 3A4). Anticarcinogenic properties of garlic compounds could be explained by the inhibition of the activities of CYPs which are able to activate carcinogens.

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Supplementary Figure 2:

Supplementary Figure 2: Enrichment of CNVs identified in this study in pericentromeric regions. The fusion that

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P Tumbale et al. Nature 000 , 1-5 (2013) doi:10.1038/nature12824

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I / I -60

Figure S1. I / I -60. 1.4. 1.0. 0.6. 0.2. 0. -80. -40. +40. +80. Conditioning potential (mV).

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AT Crombie & JC Murrell Nature 000 , 1-4 (2014) doi:10.1038/nature13192

Inactivation of PrMO had a marginal effect during growth on a mixture of methane and propane. AT Crombie & JC Murrell Nature 000 , 1-4 (2014) doi:10.1038/nature13192.

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