'Linkage disequilibrium' diaporamas de présentation

III. Modeling Selection A. Selection for a Dominant Allele B. Selection for an Incompletely Dominant Allele C.

III. Modeling Selection A. Selection for a Dominant Allele B. Selection for an Incompletely Dominant Allele C. Selection that Maintains Variation. C. Selection that Maintains Variation 1. Heterosis - selection for the heterozygote. C. Selection that Maintains Variation

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Picking SNPs Application to Association Studies

Picking SNPs Application to Association Studies. Dana Crawford, PhD SeattleSNPs PGA University of Washington March 20, 2006. Outline of Tutorial. Concepts of tagSNPs LD and haplotype definitions Haplotype blocks and definitions Tools to identify tagSNPs. Ex: E2F2.

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Dominance

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Chapter 7

Chapter 7. Evolution at Multiple Loci: Linkage, Sex, and Quantitative Genetics. Evolution at Multiple Loci. In the past two chapters we have considered the Hardy-Weinberg Equilibrium Principle for one locus at a time Can this model be extended to a two or higher locus case?

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Human Genetics

Human Genetics. Weibin Shi Michele Sale. Contact Information. Shi: ws4v@virginia.edu ; 243-9420 Sale: ms5fe@Virginia.EDU ; 982-0368 . Recommended textbooks. Medical Genetics -Jorde, Carey, Bamshad & White Mosby, ISBN 13: 978-0-323-04035-8 Human Molecular Genetics - Strachan T, Read A

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The Human Genomes

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SNPs, Haplotypes, Disease Associations

SNPs, Haplotypes, Disease Associations. Algorithmic Foundations of Computational Biology II Course 1. Prof. Sorin Istrail. SNPs and the Human Genome: The Minimal Informative Subset. Overview. Introduction: SNPs, Haplotypes A Data Compression Problem:

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Some current issues in QTL identification

Some current issues in QTL identification. Lon Cardon Wellcome Trust Centre for Human Genetics University of Oxford. Acknowledgements: Goncalo Abecasis Stacey Cherny Twin course faculty. LOD. Positional Cloning. Genetics. Chromosome Region. Association Study. Sib pairs. Genomics.

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Population Genetics in the Post-Genomic Era

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Haplotype Blocks

Haplotype Blocks. An Overview A. Polanski Department of Statistics Rice University. Key Papers. N. Patil et al., (2001), Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21, Science, vol. 294, pp. 1719-1723

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From genetics to plant breeding: What do we know and what do we need to know?

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Chapter 2: Hardy-Weinberg

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Genome evolution

Genome evolution. Lecture 3: population genetics I: mutation and recombination. Population genetics. Drift : The process by which allele frequencies are changing through generations. Mutation : The process by which new alleles are being introduced.

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Introduction to Genetic Association Studies

Introduction to Genetic Association Studies. Peter Castaldi January 28, 2013. Objectives. Define genetic association studies Historical perspective on genetic association and the development of GWAS Overview of Essential Components of a GWAS Analysis. Definitions.

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Evolution of Sex

Evolution of Sex. Evolution of Sex. Importance Nearly universal biological phenomenon What is its advantage?. II. Back to Evolution of Sex- Frequency. Asexual reproduction in an aphid. Volvox aureus , a freshwater alga. female. male. Asexual.

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rare Mendelian diseases versus common multi-factorial diseases

e.g., cystic fibrosis is one of the most common life-shortening childhood-onset inherited diseases in the United States, affecting 1 in 3900 births; one of every 31 individuals is a carrier of the recessive disease allele

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Gaucher Disease

Gaucher Disease. A Closer Look Ray Molzon. Introduction. Lysosomal storage disease (Sphingolipidose) Deficiency of glucocerebrosidase causes buildup of glucocerebroside Gaucher cells, store sphingolipid in spleen, liver, bone marrow, alveolar spaces, brain tissue. Symptoms. Anemia

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SNPs and the Human Genome

SNPs and the Human Genome. Sorin Istrail. Single Nucleotide Polymorphism (SNP). The most abundant type of polymorphism. GATTTAGATC G CGATAGAG GATTTAGATC T CGATAGAG. A SNP is a position in a genome at which two or more different bases occur in the population, each with a frequency >1%.

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Course: Animal Breeding

Course: Animal Breeding. Instructor: Dr. Jihad Abdallah New approaches in Animal Breeding. Gene detection and Gene mapping. Use of DNA marker information to locate important genes on the chromosomes: Major genes: genes which have large effect on the given trait

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