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Basic Model For Genetic Linkage Analysis Lecture #5

Basic Model For Genetic Linkage Analysis Lecture #5

Basic Model For Genetic Linkage Analysis Lecture #5. Prepared by Dan Geiger. Using the Maximum Likelihood Approach. The probability of pedigree data Pr(data | ? ) is a function of the known and unknown recombination fractions denoted collectively by ?.

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440 views • 31 slides
p57 & Beckwith-Weidemann Syndrome

p57 & Beckwith-Weidemann Syndrome

p57 & Beckwith-Weidemann Syndrome. Claire Conn. Outline. Normal Function of p57 Beckwith-Weidemann Syndrome Relationship of p57 to cancer. The Role of p57 in the Cell. Remember CDKs?. Cyclin-CDK complexes are important regulators of the cell cycle They are regulated in 3 ways:

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376 views • 27 slides
Genetic Imprinting

Genetic Imprinting

Genetic Imprinting. No parthenogenesis in mammals. Genomic imprinting and the strange case of the insulin-like growth factor II receptor . Haig D, Graham C. Cell . 64:1045-6 (1991) Maternal-Paternal Conflict Theory. The sins of the fathers and mothers: genomic imprinting

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488 views • 24 slides
& Beckwith-Wiedemann Syndrome

& Beckwith-Wiedemann Syndrome

p57. April 2 nd 2013. & Beckwith-Wiedemann Syndrome. Brandon Ballance. Beckwith-Wiedemann Syndrome. Risk of developing cancer : 7.5%. Genes Associated with BWS. CDKN1C. Genetic Imprinting. 1 in 13,700 Children . Only MATERNAL allele expressed!. CH 3. CH 3.

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718 views • 9 slides
Released 1000 Genomes indels : 328,528

Released 1000 Genomes indels : 328,528

Reference genome hg18. RD genotyping; trio phasing 94% phased. Fosmid sequenced deletions: 44. 33 events. July 30, 2010. Fosmid sequenced insertions: ~26. Phasing?. Released 1000 Genomes insertions: 97. Phasing?. Released 1000 Genomes deletions: 1,522. Trio phasing 77% phased

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166 views • 1 slides

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