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P53 allele - PowerPoint PPT Presentation

p53 Mutant Mice with Altered Cancer and Aging Phenotypes

p53 Mutant Mice with Altered Cancer and Aging Phenotypes. Larry Donehower Baylor College of Medicine Houston, Texas 77030. p53 - A Major Node in the Cellular Stress Response. ROS. Hypoxia. IR,UV. Oncogenes. Telomere loss. p53. mdm2. SirT1. Cell Cycle Arrest. Apoptosis. p66Shc. ?.

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P53 allele - PowerPoint PPT Presentation

p53 Mutant Mice with Altered Cancer and Aging Phenotypes