'Positive ion mode' diaporamas de présentation

LC/MS WORKSHOP Iowa State University K amel H arrata

LC/MS WORKSHOP Iowa State University K amel H arrata. Instrument Description Data Acquisition Data Processing. What is Mass Spectrometry?.

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???????? LC-MS Method development and Analyte Identification

???????? LC-MS Method development and Analyte Identification. ?????????? 03-12-2008. Ionization. ESI Sonic Spray I APCI APPI APLI. Ion Separation. Mass range Scan speed Mass resolution Mass accuracy. Mass Accuracy.

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Food Analysis Lecture 24 (04/23/2013)

Food Analysis Lecture 24 (04/23/2013). GC (2). Qingrong Huang Department of Food Science. Sample Injection. Direct Injection Sample Derivatization. Column. Either packed or capillary column Packaging Materials: - Packed column: silane-treated diatomaceous earth

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Ceramides are the biological building blocks of Sphingolipids

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Bio- analytical method development and validation of Valsartan by precipitation method with HPLC-MS/MS: Application to a

The most suitable bio-analytical method based on Precipitation method has been developed and validated for quantification of Valsartan in Rat plasma. Valsartan D9was used as an internal standard for Valsartan. Thermo Hypurity C18 (4.6mm x 150 mm, 5.0 µm) column provided chromatographic separation of analyte followed by detection with mass spectrometry. The method involved simple isocratic chromatographic condition and mass spectrometric detection in the positive ionization mode using an API-4000 system. The total run time was 3.0 minutes. The proposed method has been validated with the linear range of 0.50 – 20000.00 ng/mL for Valsartan. The intra-run and inter-run precision values were within 1.3 to 2.5% and 2.1 to 3.2% respectively for Valsartan. The overall recovery for Valsartan and Valsartan-D9 was 86.9% and 86.7% respectively. This validated method was successfully applied into the pharmacokinetic study of rat plasma.

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EXPERIMENTAL Derivatization

Oligo. IRABA. *. Y 3 ?. 34. Y 2. (-Glc). (-Gal). (-Fuc,-Gal,-GlcNAc). (-Fuc). IRMPD. Y 1. 1265. 446. 1119. 608. (-Hex,-HexNAc). (-Fuc). (-Hex,-Hex,-H 2 O). [LNFPI+IRABA-2H 2 O+H] +. Y 2. *. Y 0. B. Y 1. 284. 15. 412. B. (-Gal,-GlcNAc). 608. (-Fuc). (-Glc). 446.

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Gabapentin : Novel anticonvulsant drug for adjunctive therapy of partial seizures.

Simultaneous UPLC-TMS assay for the detection of Levetiracetam and Gabapentin in serum and plasma. K. Johnson-Davis 1,2 , J.M. Juenke 1 , P.I. Brown 1 , G.A. McMillin 1,2 1 ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, 2 Department of Pathology,

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