'Purifying selection' diaporamas de présentation

Functional prediction in proteins (purifying and positive selection)

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the gradualist point of view

the gradualist point of view. Evolution occurs within populations where the fittest organisms have a selective advantage. Over time the advantages genes become fixed in a population and the population gradually changes.

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MCB 371/372

MCB 371/372. positive selection 4/25/05. Peter Gogarten Office: BSP 404 phone: 860 486-4061, Email: gogarten@uconn.edu. Random Genetic Drift. Selection. 100. advantageous. Allele frequency. disadvantageous. 0.

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Thank you for viewing this presentation.

Thank you for viewing this presentation. We would like to remind you that this material is the property of the author. It is provided to you by the ERS for your personal use only, as submitted by the author. 2010 by the author. TNF. TLR2 TLR4. M. tuberculosis. M f.

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Evolution of individual genes in humans

Evolution of individual genes in humans. Are there any examples of genes that are actively evolving in humans (but which are static in other primates)? If so, how do we distinguish genes that are under POSITIVE SELECTION from those that are under PURIFYING SELECTION?. Four papers to read:.

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Purifying selection signals

Purifying selection signals. Diversifying selection signals. FEL. FEL. b). a). IFEL. IFEL. c). d). FEL not IFEL. FEL not IFEL. e). f). FEL not IFEL purifying only in subtype C. FEL not IFEL diversifying only in subtype C. h). g).

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ABSTRACT

CP RMSCC 2133. 99. threshold for significance after correction for mult. testing. CP RMSCC 3700. CP RMSCC 1037. CP RMSCC 3488. CP CPA 0001. C. posadasii. 100. CP CPA 0020. 95. CP1. 100. CP RMSCC 1038. CPS2. 99. 99. CP CPA 0066. CI RMSCC 2394. C. immitis. 100. 73 kb cds

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ABSTRACT

CP RMSCC 2133. 99. threshold for significance after correction for mult. testing. CP RMSCC 3700. CP RMSCC 1037. CP RMSCC 3488. CP CPA 0001. C. posadasii. 100. CP CPA 0020. 95. CP1. 100. CP RMSCC 1038. CPS2. 99. 99. CP CPA 0066. CI RMSCC 2394. C. immitis. 100. 73 kb cds

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