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CHAPTER 15

CHAPTER 15

CHAPTER 15. Cell Signaling and Signal Transduction: Communication Between Cells. Signal transduction. Extracellular ligand: 1st messenger Autocrine: ligand binds to producing cell Paracrine: ligand binds to a neighbor cell

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The STAT family

The STAT family

The STAT family. Class IIB(3)(b) latent cytoplasmic factors. These families not present in fungi or plants, hinting at an important evolutionary divergence leading to animals. STATs - a signal responsive TF family. STAT s: S ignal T ransducers and A ctivators of T ranscription

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LECT 24: CELL SIGNAL TRANSDUCTION

LECT 24: CELL SIGNAL TRANSDUCTION

LECT 24: CELL SIGNAL TRANSDUCTION. Cells respond to molecular cues they receive: from neighboring cells or extracellular matrices (paracrine factors), from the circulation (hormones and metabolites), and from outside the body (sensory inputs).

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Receptor tyrosine kinases

Receptor tyrosine kinases

Receptor tyrosine kinases. Introduction: Protein phosphorylation Recruitment of kinases in signalling pathways Consequences of protein phosphorylation RTK family: Classification & structure/function RTK ligands Receptor dimerization & autotransphosphorylation. Receptor tyrosine kinases.

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EGF Receptor Signal Transduction Pathway

EGF Receptor Signal Transduction Pathway

EGF Receptor Signal Transduction Pathway. SIGMA-ALDRICH. EGF Receptor Signal Transduction Pathway

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