'Structure alignment' diaporamas de présentation

BIOINFORMATICS Structures

BIOINFORMATICS Structures. Mark Gerstein, Yale University gersteinlab.org/courses/452 (last edit in spring '11). What Structures Look Like? Structural Alignment by Iterated Dynamic Programming RMS Superposition Rotating and Translating Structures Scoring Structural Similarity

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Protein Structure

Protein Structure. Why study protein structure?. Studying the structure model allows better understanding of the structure-function relationship, and is an important starting point for many kinds of research. F. F. Structure determination. Crystallography:

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BIOINFORMATICS Structures

BIOINFORMATICS Structures. Mark Gerstein, Yale University gersteinlab.org/courses/452 (last edit in spring '10 after class #6, including in-class changes & edits). class #4 continues from last ppt. What Structures Look Like? Structural Alignment by Iterated Dynamic Programming

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Tutorial: Bioinformatics Resources ( http://pir.georgetown.edu/~huz/class/bioinfo_resource.html )

Tutorial: Bioinformatics Resources ( http://pir.georgetown.edu/~huz/class/bioinfo_resource.html ) . Bio-Trac 25 (Proteomics: Principles and Methods) March 24, 2006 Zhang-Zhi Hu, M.D. Senior Bioinformatics Scientist, Protein Information Resource Research Assistant Professor, Department of

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Macromolecular structure

Bioinformatics. Macromolecular structure. Contents. Determination of protein structure Structure databases Secondary structure elements (SSE) Tertiary structure Structure analysis Structure alignment Domain recognition Structure prediction Homology modelling

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Multiple Sequence Alignment

Multiple Sequence Alignment. ?????????? ??? 2004/05/31. What is a multiple alignment?. An alignment of ten I-set immunoglobin superfamily. Motivation. A multiple alignment may suggest a common structure of the protein products; a common function; a common evolutionary source. Issues.

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MSDfold (SSM) A web service for protein structure comparison and structure searches

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Protein Strucure Comparison

Protein Strucure Comparison. Chapter 6,7 Orengo. Describing Coarse Level Structure. Helices. ? -helix 4-turn helix, min. 4 residues 3 10 -helix 3-turn helix, min. 3 residues ? -helix 5-turn helix, min. 5 residues. Formed by H-Bonds between residues in the same helix.

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(Quantitative) Structure-Activity Relationships (Q)SAR

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Local Flexibility Aids Protein Multiple Structure Alignment

Local Flexibility Aids Protein Multiple Structure Alignment. Matt Menke Bonnie Berger Lenore Cowen. The Protein Multiple Structure Alignment Problem. Input: The 3D coordinates of the atomic structures of k proteins

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Eugene Krissinel SSM - MSDfold

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PDBe-fold (SSM) A web-based service for protein structure comparison and structure searches

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PDBe-fold (SSM) A web-based service for protein structure comparison and structure searches

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Structure Alignment in Polynomial Time

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MSDfold (SSM) S econdary S tructure M atching

MSDfold (SSM) S econdary S tructure M atching A web service for protein structure comparison and structure searches Eugene Krissinel. http://www.ebi.ac.uk/msd-srv/ssm/ssmstart.html. Structure alignment.

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Constrained Multiple Structure Feature Alignment (CMSFA)

Constrained Multiple Structure Feature Alignment (CMSFA). ??? , ??? , ??? , ??? , ??? , ??? NCS2005. Abstract.

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Based on: MicroRNA identification based on sequence and structure alignment

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Using structure alignment tools

Using structure alignment tools. Structure alignment. View a structural alignment of the P53 1T4F protein with Catalytic And Tetramerization Domains From Rat 2TOH protein. Look at the similarities and differences between these two proteins. Structure alignment with VAST.

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Accuracy of structure-based sequence alignment of automatic (structure-alignment) methods

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Bioinformatics

Biological Data. Computer Calculations. +. Bioinformatics. Bioinformatics Topics for 2006. Overview of Full Range of Topics in Bioinformatics Details on "Classic" (core) Bioinformatics Comparing Sequences Dynamic Programming, Substitution Matrices, Scoring Systems and P-values

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