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Systemic diseases damage - PowerPoint PPT Presentation

Ch. 16. Tolerance and Autoimmunity Tolerance sometimes is broken

Ch. 16. Tolerance and Autoimmunity Tolerance sometimes is broken - self reactive cells do form, but are usually inactivated or suppressed Failure of tolerance leads to autoimmunity Damage can be antibody-mediated and/or T-cell mediated Systemic vs. organ-specific

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Autoimmunity Tolerance sometimes is broken self reactive cells do form, but are usually

Autoimmunity Tolerance sometimes is broken self reactive cells do form, but are usually inactivated or suppressed Damage can be antibody- or T-cell mediated Some disease are systemic, others organ- specific. Organ-specific target is a molecule unique to that organ

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328 views • 19 slides

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Ch. 16. Tolerance and Autoimmunity Tolerance sometimes is broken

Autoimmunity Tolerance sometimes is broken self reactive cells do form, but are usually