'Tgf' diaporamas de présentation

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TGF- b Superfamily

Conserved ligands, cell-surface receptors and signaling co-receptors from C. elegans to humans 3 subfamilies: TGF-b, activin/inhibin/nodal, BMP Ligands are both homodimers or heterodimers with a set of 7 cysteines: 3 intrasubunit disulfide bonds + 1 intersubunit bond

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Intestinal Radiation-Induced Fibrosis (RIF)

Intestinal Radiation-Induced Fibrosis (RIF). Fibrosis is the presence of excessive collagen in an organ or tissue. In the intestine, it is characterized by the fibrogenic differentiation of resident mesenchymal cells and accumulation of extracellular matrix ( ECM ). PATHOLOGY.

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Evgeniya Solodova 01.12.08

Evgeniya Solodova 01.12.08. Introduction: Regulatory cytokine transforming growth factor-? ( TGF-? ): is a secreted protein that exists in three isoforms called TGF-?1, TGF-?2 and TGF-?3 TGF-?1 is the founding and predominant member of this family

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John A. Mkpa Claflin University/University of South Carolina Cancer Research Training Program

The Effects of Histone Deacetylase Inhibitor on the Expression of TGF- ? Sensitivity in HKc/DR Cells. John A. Mkpa Claflin University/University of South Carolina Cancer Research Training Program. Cervical Cancer. Approximately 500,000 cases worldwide (Globocan, 2000)

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Transforming Growth Factor-Beta Receptor 2 TGF- ? receptor 2

Transforming Growth Factor-Beta Receptor 2 TGF- ? receptor 2. In gastric cancer. 7 exons. Gene Information. TGF- ? receptor 2, also called, TGF ? RII or T ? RII is located at 3p22.

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Non differentiated VSM cell

Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels . (Wikipedia). Differentiation of VSM cells. Non differentiated VSM cell. Differentiated VSM cell. +TGF- ? +BMP. SMA, CNN1. (Non-contractile).

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802.11F Meeting Report April 2002

802.11F Meeting Report April 2002. Goals for April Mtg. This Interim meeting agenda is limited to the following subjects: Completing LB 32 comment resolutions. Completing Draft 3.1 to reflect the comment resolutions

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Transforming Growth Factor ? Receptor Type II

Transforming Growth Factor ? Receptor Type II. Tina Morris. http://en.wikipedia.org/wiki/TGF_beta_receptor_2. What is TGF- ? R2?. A transmembrane serine/threonine kinase A tumor suppressor Important in mammalian development Required for growth inhibition in colon. The TGF- ? Pathway.

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TGF- ? receptor 1

TGF- ? receptor 1. Anshul Badhwar. Transforming Growth Factor ? - receptor type I / ALK5. Serine/Threonine kinase receptor. Transforming Growth Factor ? - receptor type I. Serine/Threonine kinase receptor . Involved in both tumor suppression and promotion.

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SUPPLEMENTARY FIGURES

SUPPLEMENTARY FIGURES. Supp. 1. MCF7. SKOV-3. TGF- ?3 TGF- ?2 TGF- ?1. - - -. TGF- ?3 TGF- ?2 TGF- ?1. - + -. - - +. + - -. - - -. + - -. - + -. - - +. A. Par-4. Par-4. ?-a ctin. ?-a ctin. *. ***. *. MCF7. SKOV-3. B. TGF- ?3 TGF- ?2 TGF- ?1. - - -.

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CFSE

a. +Th17 IL-1 b. +Th17 TGF- b 1. B16-ova. EL-4. -Glu +Pyru media. Complete media. B16-ova. CFSE gated. EL-4. CD25. No T cells. 7AAD. CFSE. +Th17 TGF- b 1. +Th17 IL-1 b. Annexin V. CD69. +Th17 IL-1b (- Glu + Pyru ). c. +Th17 IL-1b (complete media). b. B16-ova. EL-4.

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Signaling Pathway of TGF- ?

Signaling Pathway of TGF- ?. SIGMA-ALDRICH. Signaling Pathway of TGF- ?

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Mock

Supplementary Fig 1. Mock. NDRG2. A. **. 1.25. Integrin ? 6. 1.00. Fold induction. 0.75. PAI-1. 0.50. NDRG2. 0.25. GAPDH. 0.00. Mock. NDRG2. B. Real time PCR.

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NM-np

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SMAD 2/3

+. -. cytoplasmic extract. -. +. nuclear extract. p125 FAK. PCNA. I k B a. A. TGF b1. TGF b 1 + a V b 6 block. Ab. TGF b 1 + TGF b -R II block. Ab. TGF b 1. TGF b 1 + a V b 6 block. Ab. TGF b 1 + TGF b -R II block. Ab. control. control. C. N. C. N. C. N. C. N. C.

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% over control

B. A. LCTC. LCTC. SF. SF. *. % over control. % over control. *. *. *. *. 5. 10. 20. 40. 0.01. 0.05. 0.1. 1.0. TGF- ? concentration (n g/ml). PDGF AA concentration (n g/ml). C. D. 3. 4. TGF- ?. TGF- ?. No TGF- ?. No TGF- ?. 3. 2. DPM (x 10 -3 ). DPM (x 10 -3 ). 2.

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ML Shi et al. Nature 474 , 343 - 349 (2011) doi:10.1038/nature10152

ProTGF- ? 1 complexes with LTBP and ? v ? 6 integrin, and activation of TGF- ?. ML Shi et al. Nature 474 , 343 - 349 (2011) doi:10.1038/nature10152.

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