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VectorBase

VectorBase. Invertebrate Vectors of Human Pathogens . Lots of data out there… Data on : Distribution of vectors and their ecology Insecticide resistance Transmission capacity For diseases : Malaria , Chagas , Dengue, Lymph. filariasis , etc. Projects funded by :

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VectorBase

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  1. VectorBase Invertebrate Vectors of Human Pathogens

  2. Lots of data out there… • Data on: • Distribution of vectors and their ecology • Insecticide resistance • Transmission capacity • For diseases: • Malaria, Chagas, Dengue, Lymph. filariasis, etc. • Projects funded by: • Innovative Vector Control Consortium - IVCC • The WHO/Gates Foundation Vector Biology and Control Project - VBC • African Network on Vector Research - ANVR • Marathon Oil (and other private investors) • And several more, including national programmes • Problems: • Fragmentation of data; Secrecy; Independence; “Dialects” and syntax; etc.

  3. The answer, is... Intelligent Databases Open access Decision Support Systems Interoperability Efficient searches

  4. 3610 (2392 unique)

  5. IRBase

  6. The example of Insecticide Resistance: Aedes aegypti, 2098 records

  7. The example of Insecticide Resistance: Aedes aegypti, 2098 records

  8. The example of Insecticide Resistance: Aedes aegypti - DDT, 133 records

  9. The example of Insecticide Resistance: Anopheles gambiae, 771 records

  10. The example of Insecticide Resistance: A. gambiae - DDT, 198 records

  11. The example of Insecticide Resistance: A. gambiae - permethrin, 190 records

  12. is_a participates_in MIRO: resistance assay CHEBI: insecticide OBI/MIRO: assay IDOMAL: Transmission detection assay is_a has_output is_a MIRO: resistance PATO: Phenotype has_input has_output has_quality MIRO: Organism VB_CV: genotype IDOMAL: Human biting rate Sporozoite rate Parous rate Vectorial capacity IDOMAL: Human population has_member VB_CV/MIRO: Mosquito population Season + Geolocation + Human population + Mosq. population located_in has_output is_a GAZ: Geolocation OBI/MIRO: collection assay is_a has_quality is_about has_input ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity GAZ: Country, Province, District, GPS coordinates IDOMAL: Season IDOMAL: Malaria control measures

  13. is_a participates_in MIRO: resistance assay CHEBI: insecticide OBI/MIRO: assay IDOMAL: Transmission detection assay is_a has_output is_a MIRO: resistance PATO: Phenotype has_input has_output has_quality MIRO: Organism VB_CV: genotype IDOMAL: Human biting rate Sporozoite rate Parous rate Vectorial capacity IDOMAL: Human population has_member VB_CV/MIRO: Mosquito population Season + Geolocation + Human population + Mosq. population located_in has_output is_a GAZ: Geolocation OBI/MIRO: collection assay is_a has_quality is_about has_input ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity GAZ: Country, Province, District, GPS coordinates IDOMAL: Season IDOMAL: Malaria control measures

  14. is_a participates_in "VIRO": resistance assay CHEBI: insecticide OBI/"VIRO": assay "IDOVBD": Transmission detection assay is_a has_output is_a "VIRO": resistance PATO: Phenotype has_input has_output has_quality "VIRO": Organism VB_CV: genotype "IDOVBD": Transmission data relating to vectors of other vector-borne diseases "VIRO": Human population has_member VB_CV/"VIRO": Vectorpopulation Season + Geolocation + Human population + Vector population located_in has_output is_a “Oth_Ont1”: Additional data models GAZ: Geolocation OBI/"VIRO": collection assay is_a has_quality is_about has_input ENVO : Environmental conditions e.g. Rice field, Irrigation scheme, swamp, altitude, av. temperature, annual rainfall, av. humidity GAZ: Country, Province, District, GPS coordinates "IDOVBD": Disease control measures "IDOVBD": Season “Oth_Ont2”: Additional data models "IDOVBD": Additional data models “VBDbase”

  15. PopGen in VectorBase George Christophides, with Bob MacCallum and Seth Redmont Kitsos Louis, with Emmanuel Dialynas and PantelisTopalis A new section of VB being developed that will house data on the population biology of anophelines, as well as data on malaria transmission and IR.

  16. PATO IDOMAL GAZ UO Soon to come in VectorBase! IDOMAL IDOMAL VBCV Linking PopGen and ontologies; Phenotypes, IR, transmission and popu- lation/ecology data

  17. TGMA – Mosquito Anatomy Ontology; CARO/BFO • TADS – Tick Anatomy Ontology; CARO/BFO • MIRO – Ontology of Insecticide Resistance; (move) to IDOMAL • IDOMAL – Malaria Ontology; IDO/BFO • VBCV – Ontology/CV for “completion” of PopGen • IDOMAL extension, “IDOChagas”, PLO (Parasite Lifecycle) with PritiParykh, Chris Stoeckertet al.

  18. LOGICAL THOUGHT IS NOT A PRIVILEGE OF A FEW IT’S AN OBLIGATION FOR EVERYONE !!!

  19. Thank you!

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