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DAT

PKC phosphorylates the transporter. DAG and AA both stimulate the activity of Protein Kinase C (PKC). PLA2 produces arachidonic acid. PLC produces IP3 and DAG. High intracellular pH stimulates Phospholipase A2 action. Transporter of the amphetamine and Na+ lead to an AMPH and Na+ build up.

september
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DAT

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  1. PKC phosphorylates the transporter DAG and AA both stimulate the activity of Protein Kinase C (PKC) PLA2 produces arachidonic acid PLC produces IP3 and DAG High intracellular pH stimulates Phospholipase A2 action Transporter of the amphetamine and Na+ lead to an AMPH and Na+ build up Ca2+ buildup stimulates phospholipase C (PLC) AMPH buildup increases intracellular pH Na+ buildup inhibits Ca2+ eflux, leading to Ca2+ buildup DAT P P P 8 Ca2+ AMPH Na+ PLA2 AA IP3 PLC DAG PKC AMPH Na+ pH ~7 Ca2+ Na/Ca antiporter

  2. Normal Vesicular release of neurotransmitter 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular Intracellular

  3. Normal Vesicular release of neurotransmitter 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular Intracellular

  4. Normal Vesicular release of neurotransmitter Extracellular 5-HT 5-HT 5-HT 5-HT 5-HT Intracellular 5-HT 5-HT 5-HT 5-HT

  5. Normal Vesicular release of neurotransmitter 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular Intracellular

  6. Normal uptake of neurotransmitter 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular 5-HT Intracellular

  7. Normal uptake of neurotransmitter 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular 5-HT Intracellular 5-HT 5-HT 5-HT 5-HT

  8. Phosphorylation of Transporter creates conformational change P P P P PKC 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular Intracellular 5-HT 5-HT 5-HT 5-HT

  9. Conformational change “creates” intracellular binding site, favoring reverse transport P P P P PKC 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT 5-HT Extracellular Intracellular 5-HT 5-HT 5-HT 5-HT 5-HT

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