1 / 53

Potential Improvement in Photodynamic Therapy for Cancer

Potential Improvement in Photodynamic Therapy for Cancer. Senior Seminar - Journal Club Beloit College. Charles Abrams January 25, 2002. Cyclodextrin Dimers as Cleavable Carriers of Photodynamic Sensitizers. Baugh, S.D.P., Breslow, R.*, et.al. J. Am. Chem. Soc. 2001 , 123 , 12488.

shae
Télécharger la présentation

Potential Improvement in Photodynamic Therapy for Cancer

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Potential Improvement inPhotodynamic Therapy for Cancer Senior Seminar - Journal Club Beloit College Charles Abrams January 25, 2002

  2. Cyclodextrin Dimers as Cleavable Carriers of Photodynamic Sensitizers Baugh, S.D.P., Breslow, R.*, et.al. J. Am. Chem. Soc.2001, 123, 12488.

  3. What is Photodynamic Therapy ?

  4. What is Photodynamic Therapy ? Human figure from A.D.A.M. Inside Story, A.D.A.M. Software, Atlanta, 1994.

  5. What is Photodynamic Therapy ? National Cancer Institute website, cis.nci.nih.gov/fact/7_7.htm accessed 1/17/02

  6. What is Photodynamic Therapy ? visible laser National Cancer Institute website, cis.nci.nih.gov/fact/7_7.htm accessed 1/17/02

  7. What is Photodynamic Therapy ? visible laser National Cancer Institute website, cis.nci.nih.gov/fact/7_7.htm accessed 1/17/02

  8. What is Photodynamic Therapy ? National Cancer Institute website, cis.nci.nih.gov/fact/7_7.htm accessed 1/17/02

  9. What is Photodynamic Therapy ? This sucks! Patient must avoid sunlight! National Cancer Institute website, cis.nci.nih.gov/fact/7_7.htm accessed 1/17/02

  10. New Idea: Encapsulate Photosensitizers Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  11. New Idea: Encapsulate Photosensitizers Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  12. New Idea: Encapsulate Photosensitizers visible laser Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  13. New Idea: Encapsulate Photosensitizers visible laser Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  14. New Idea: Encapsulate Photosensitizers visible laser Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  15. New Idea: Encapsulate Photosensitizers visible laser Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  16. New Idea: Encapsulate Photosensitizers visible laser Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  17. New Idea: Encapsulate Photosensitizers visible laser Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  18. New Idea: Encapsulate Photosensitizers Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  19. New Idea: Encapsulate Photosensitizers Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  20. Encapsulate withcyclodextrin dimerswhich havephotocleavable linkers Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  21. What Is Cyclodextrin?

  22. What Is Cyclodextrin?

  23. What Is Cyclodextrin?

  24. What Is Cyclodextrin?

  25. What Is Cyclodextrin?

  26. What Is Cyclodextrin? Cyclodextrin 3D structure from Chem3D

  27. What Is Cyclodextrin?

  28. Why a Cyclodextrin Dimer? Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  29. Why a Cyclodextrin Dimer? Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  30. Why a Cyclodextrin Dimer? Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  31. Why a Cyclodextrin Dimer? Möser, J.G.; Ruebner, A.; et.al. in Proc. 8th Internat. Symp. on Cyclodextrins; Szetli, J.Ed. Kluwer: Boston 1996; pp71-76

  32. What Is The Linker? Ruebner, A., Breslow, R., et. al.PNAS1999, 14692.

  33. What Is The Linker? Ruebner, A., Breslow, R., et. al.PNAS1999, 14692.

  34. What Is The Linker? Ruebner, A., Breslow, R., et. al.PNAS1999, 14692.

  35. What Is The Linker? Ruebner, A., Breslow, R., et. al.PNAS1999, 14692.

  36. Dimer Structures

  37. Linker Design 22 Å 20 Å 18 Å 16 Å Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  38. Photosensitizers phthalocyanines Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  39. Photosensitizers phthalocyanines Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488. Supplementary material, p. S14

  40. Photosensitizers Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  41. Photosensitizers Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  42. Photosensitizers 25 Å 23 Å 23 Å 17 Å Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  43. Photosensitizers Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  44. Binding Study

  45. Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  46. Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  47. Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  48. Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  49. Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

  50. Baugh, S.D.P, Breslow, R., et. al.JACS2001, 123, 12488.

More Related