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Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Mike Lin. NSAIDs. Therapeutic Effects List of NSAIDs Anatomic Pathway Mechanism Aspirin & Ibuprofen Side Effects. Therapeutic Effects. Analgesic: Reduction of pain perception Antipyretic: Reduction in fever Anti-Inflammatory:

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Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

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  1. Nonsteroidal Anti-Inflammatory Drugs(NSAIDs) Mike Lin

  2. NSAIDs • Therapeutic Effects • List of NSAIDs • Anatomic Pathway • Mechanism • Aspirin & Ibuprofen • Side Effects

  3. Therapeutic Effects • Analgesic: • Reduction of pain perception • Antipyretic: • Reduction in fever • Anti-Inflammatory: • Reduction of inflammation/swelling

  4. List of NSAIDs

  5. Anatomic Pathway • Damaged tissue causes the release of Prostaglandins from Cyclooxygenase Enzymes: • Prostaglandins • Lipid compounds that have a hormone-like effect • Stimulate nerve endings to send pain signals to the brain via the CNS • Cyclooxygenase Enzyme (COX): • COX1 - Maintenance of gastrointestinal tract and blood platelets • COX2 - Related to inflammation and pain responses

  6. Mechanism • NSAIDs inhibit COX enzymes: • Aspirin irreversibly modifies COX enzymes to no longer function • Ibuprofen competitively blocks substrate binding sites on enzymes • AspirinIbuprofen

  7. Aspirin

  8. Ibuprofen

  9. Side Effects • Blood thinning due to lack of blood clotting • Stomach ulcers from degradation of stomach lining • Kidney failure from prolonged use

  10. Summary • NSAIDs - Nonsteroidal Anti-Inflammatory Drugs • Reduce PAIN, FEVER, and INFLAMMATION • Function by inhibiting COX Enzymes from producing Prostaglandins • Chronic overuse can lead to serious health issues and damage

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