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DNA REPLICATION

DNA REPLICATION. Nucleosid. Nucleotid & Nucleosid. Figure 07.08. Figure 07.09. Figure 07.18. Polymerization of the deoxynucleotides during DNA synthesis. The β and γ phosphates of each deoxynuleosid triphosphate are cleaved off to give energy for the polymerization reaction.

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DNA REPLICATION

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  1. DNA REPLICATION

  2. Nucleosid Nucleotid & Nucleosid

  3. Figure 07.08

  4. Figure 07.09

  5. Figure 07.18

  6. Polymerization of the deoxynucleotides during DNA synthesis. The β and γ phosphates of each deoxynuleosid triphosphate are cleaved off to give energy for the polymerization reaction

  7. A single base can be flipped out from the double helix,which could be important in recombination and repair

  8. Figure 01.11

  9. Figure 09.23

  10. DNA polymerase { ΙΙΙ , Ι } • Nuclease { endonuclease , exonuclease [ 5´,3´ exonuclease]} • DNA ligase • Primase • Accessory proteins : 10 different protein: β clamp → dnaN gene , clamp loader → help the β clamp • Helicases and helix- desabilizing proteins or single strand DNA binding proteins • Topoisomerases

  11. Figure 09.18

  12. ori C

  13. Initiation of replication at E.coli oriC

  14. DNA Repair • Mismatch repair • Excision repair • Recombination repair • SOS repair

  15. Mismatch repair(methyl-directed mismatch repair)

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