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Cumulative Risk of Diagnosis of Cancer After Start of Dialysis 1963 to Mar-2002

Cumulative Risk of Diagnosis of Cancer After Start of Dialysis 1963 to Mar-2002. Australia and NZ. Patients at Risk (30,892). 64. 473. 3913. Cumulative Risk of Diagnosis of Cancer Post Transplantation (Cadaveric Donors) 1963 to Mar-2002. Australia and NZ.

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Cumulative Risk of Diagnosis of Cancer After Start of Dialysis 1963 to Mar-2002

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  1. Cumulative Risk of Diagnosis of Cancer After Start of Dialysis 1963 to Mar-2002 Australia and NZ Patients at Risk (30,892) 64 473 3913

  2. Cumulative Risk of Diagnosis of Cancer Post Transplantation (Cadaveric Donors) 1963 to Mar-2002 Australia and NZ Patients at Risk (8,881) 118 370 2436

  3. Survival Following Diagnosis of Cancer 1963 to 31 March 2002All first Cancers Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  4. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Colon Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  5. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Bladder Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  6. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Female Breast Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  7. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Kidney Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  8. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Melanoma Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  9. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Trachea, Bronchus, Lung Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  10. Survival Following Diagnosis of Cancer 1963 to 31 March 2002Lymphoma Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Pre-ESRF Post transplant Dialysis

  11. Figure 10.3 Risk of Diagnosis of Cancer * Following Commencement of Dialysis (n=30,892) 1963 to 31 March 2002 Observed Expected Risk 95% Confidence Site of Cancer Cancer Cancer Ratio Interval ALIMENTARY TRACT 226 97.00 2.33 2.04, 2.66 Buccal Cavity 19 23.07 0.82 0.52, 1.30 Pharynx 5 4.70 1.06 0.44, 2.58 Oesophagus 16 8.79 1.82 1.11, 3.00 Stomach 26 21.41 1.21 0.82, 1.79 Small Intestine 5 1.28 3.91 1.57, 9.71 Colon 78 63.02 1.24 0.99, 1.55 Rectum & Anus 28 41.27 0.68 0.47, 0.98 Liver 16 4.72 3.39 2.04, 5.63 Gall Bladder & Extra Hepatic Bile Ducts 4 5.83 0.69 0.26, 1.84 Pancreas 13 15.23 0.85 0.49, 1.48 RESPIRATORY 163 95.82 1.70 1.46, 1.99 Larynx 7 5.92 1.18 0.56, 2.50 Trachea, Bronchus & Lung 153 86.65 1.77 1.50, 2.07 Pleura 3 3.25 0.92 0.29, 2.89 BONE 2 0.82 2.44 0.59, 10.09 CONNECTIVE TISSUE 0 4.95 BREAST 89 72.57 1.23 0.99, 1.51 Breast - female 88 71.82 1.23 0.99, 1.51 Breast - male 1 0.75 1.33 0.18, 9.72 GENITO-URINARY 319 228.66 1.40 1.25, 1.56 Cervix - In situ 9 2.7 3.33 1.70, 6.55 Cervix - Invasive 9 5.84 1.54 0.79, 2.99 Uterus 11 13.48 0.82 0.45, 1.48 Ovary 8 7.79 1.03 0.51, 2.07 Vulva & Vagina 3 2.04 1.47 0.47, 4.64 Prostate 55 150.07 0.37 0.28, 0.48 Testis 1 1.9 0.53 0.07, 3.78 Penis 1 0.68 1.47 0.20, 10.75 Bladder 103 24.98 4.12 3.37, 5.04 Kidney 91 19.01 4.79 3.86, 5.93 Ureter 15 0.16 93.75 39.58, 222.08 CENTRAL NERVOUS SYSTEM 19 10.76 1.77 1.12, 2.79 [ excluding lymphoma] ENDOCRINE GLANDS 28 4.01 6.98 4.70, 10.37 Thyroid 24 3.97 6.05 3.96, 9.24 Parathyroid 3 0.00 Other Endocrine 1 0.03 33.33 2.63, 421.94 LYMPHOMA 28 25.33 1.11 0.76, 1.61 Lymphoproliferative 0 CNS 2 0.00 Non-Hodgkins Disease 22 23.61 0.93 0.61, 1.42 Hodgkins Disease 4 1.71 2.34 0.86, 6.38 MULTIPLE MYELOMA 28 8.81 3.18 2.17, 4.66 LEUKAEMIA 14 19.82 0.71 0.42, 1.20 KAPOSI SARCOMA 4 0.27 14.81 4.84, 45.30 MALIGNANT MELANOMA 62 46.42 1.34 1.04, 1.72 MISCELLAENOUS 15 4.28 3.50 2.08, 5.92 TOTAL 1034 ** 737.81 1.40 1.32, 1.49 * Non-Melanotic skin cancers are not included ** The 1034 cancers occurred in 972 (3.1%) patients

  12. Figure 10.4 Risk of Diagnosis of Cancer * Following Cadaveric Renal Transplantation (n=8881) 1963 to 31 March 2002 Observed Expected Risk 95% Confidence Site of Cancer Cancer Cancer Ratio Interval ALIMENTARY TRACT 226 97.00 2.33 2.05, 2.65 Buccal Cavity 37 15.71 2.36 1.70, 3.26 Pharynx 8 2.85 2.81 1.40, 5.64 Oesophagus 18 3.99 4.51 2.83, 7.20 Stomach 13 9.30 1.40 0.81, 2.41 Small Intestine 1 0.85 1.18 0.16, 8.41 Colon 81 31.19 2.60 2.09, 3.23 Rectum & Anus 34 21.55 1.58 1.13, 2.21 Liver 16 2.04 7.84 4.75, 12.94 Gall Bladder & Extra Hepatic Bile Ducts 5 2.70 1.85 0.77, 4.47 Pancreas 13 6.82 1.91 1.10, 3.29 RESPIRATORY 99 46.14 2.15 1.76, 2.61 Larynx 7 3.50 2.00 0.95, 4.21 Trachea, Bronchus & Lung 87 40.88 2.13 1.72, 2.63 Pleura 5 1.77 2.82 1.17, 6.83 BONE 4 0.75 5.33 1.97, 14.42 CONNECTIVE TISSUE 4 3.44 1.16 0.44, 3.11 BREAST 59 56.15 1.05 0.81, 1.36 Breast - female 58 55.72 1.04 0.80, 1.35 Breast - male 1 0.43 2.33 0.32, 16.73 GENITO-URINARY 350 99.79 3.51 3.16, 3.89 Cervix - In situ 72 4.19 17.18 13.50, 21.88 Cervix - Invasive 15 4.96 3.02 1.82, 5.04 Uterus 13 8.88 1.46 0.85, 2.53 Ovary 4 5.94 0.67 0.25, 1.80 Vulva & Vagina 44 1.24 35.48 25.66, 49.06 Prostate 34 49.30 0.69 0.49, 0.97 Testis 4 3.18 1.26 0.47, 3.36 Penis 7 0.39 17.95 8.24, 39.09 Bladder 71 10.87 6.53 5.16, 8.27 Kidney 72 10.79 6.67 5.28, 8.44 Ureter 14 0.06 233.33 104.33, 521.86 CENTRAL NERVOUS SYSTEM 11 8.51 1.29 0.71, 2.34 [excluding lymphoma] ENDOCRINE GLANDS 19 3.94 4.82 3.06, 7.60 Thyroid 16 3.92 4.08 2.49, 6.70 Parathyroid 1 0.00 Other Endocrine 2 0.02 100.00 17.48, 572.13 LYMPHOMA 166 16.84 9.86 8.44, 11.51 Lymphoproliferative 17 0.00 CNS 16 0.00 Non-Hodgkins Disease 129 14.91 8.65 7.26, 10.31 Hodgkins Disease 4 1.94 2.06 0.77, 5.52 MULTIPLE MYELOMA 11 4.40 2.50 1.38, 4.53 LEUKAEMIA 29 10.34 2.80 1.94, 4.05 KAPOSI SARCOMA 19 0.25 76.00 44.29, 130.40 MALIGNANT MELANOMA 130 36.49 3.56 3.00, 4.23 MISCELLAENOUS 73 14.66 4.98 3.95, 6.28 TOTAL 1200 ** 398.46 3.01 2.86, 3.18 * Non-Melanotic skin cancers are not included ** The 1200 cancers occurred in 1072 (12%) patients

  13. Figure 10.5 Risk of Diagnosis of Cancer * Following Living Related Donor Renal Transplantation (n=1808) 1963 to 31 March 2002 Observed Expected Risk 95% Confidence Site of Cancer Cancer Cancer Ratio Interval ALIMENTARY TRACT 18 5.98 3.01 1.90, 4.77 Buccal Cavity 6 1.33 4.51 2.03, 10.05 Pharynx 1 0.18 5.56 0.78, 39.67 Oesophagus 2 0.21 9.52 2.37, 38.35 Stomach 2 0.51 3.92 0.98, 15.72 Small Intestine 0 0.05 Colon 4 1.83 2.19 0.82, 5.83 Rectum & Anus 1 1.23 0.81 0.11, 5.77 Liver 1 0.11 9.09 1.27, 65.19 Gall Bladder & Extra Hepatic Bile Ducts 0 0.15 Pancreas 1 0.38 2.63 0.37, 18.73 RESPIRATORY 5 2.40 2.08 0.87, 5.00 Larynx 0 0.19 0.00 Trachea, Bronchus & Lung 5 2.11 2.37 0.99, 5.69 Pleura 0 0.10 0.00 BONE 0 0.11 0.00 CONNECTIVE TISSUE 2 0.36 5.56 1.38, 22.30 BREAST 8 4.36 1.83 0.92, 3.67 Breast - female 8 4.33 1.85 0.92, 3.69 Breast - male 0 0.03 GENITO-URINARY 49 6.36 7.70 5.84, 10.17 Cervix - In situ 20 0.85 23.53 15.12, 36.61 Cervix - Invasive 3 0.55 5.45 1.75, 16.96 Uterus 3 0.57 5.26 1.69, 16.36 Ovary 1 0.42 2.38 0.33, 16.94 Vulva & Vagina 9 0.09 100.00 50.18, 199.28 Prostate 1 1.90 0.53 0.07, 3.74 Testis 1 0.66 1.52 0.21, 10.77 Penis 1 0.03 33.33 4.52, 245.79 Bladder 3 0.59 5.08 1.64, 15.81 Kidney 6 0.68 8.82 3.95, 19.70 Ureter 1 0.00 CENTRAL NERVOUS SYSTEM 2 0.79 2.53 0.63, 10.14 [ excluding lymphoma ] ENDOCRINE GLANDS 2 0.5 4.0 1.00, 16.03 Thyroid 2 0.49 4.08 1.02, 16.36 Parathyroid 0 0.00 Other Endocrine 0 0.01 0.00 LYMPHOMA 19 1.54 12.34 7.86, 19.36 Lymphoproliferative 5 0.00 CNS 0 0.00 Non-Hodgkins Disease 13 1.20 10.83 6.28, 18.69 Hodgkins Disease 1 0.34 2.94 0.41, 20.94 MULTIPLE MYELOMA 1 0.26 3.85 0.54, 27.41 LEUKAEMIA 1 0.77 1.30 0.18, 9.23 KAPOSI SARCOMA 3 0.04 75.00 23.04, 244.10 MALIGNANT MELANOMA 12 3.90 3.08 1.75, 5.41 MISCELLAENOUS 3 0.87 3.45 1.11, 10.71 TOTAL 125 ** 28.20 4.43 3.74, 5.25 * Non-Melanotic skin cancers are not included ** The 125 cancers occurred in 114 (6.3%) patients

  14. Figure 10.6 Survival Following Diagnosis of Cancer 1963 to 31 March 2002 Median Mean Standard Treatment Survival Age Deviation Total 95% Confidence Site of Cancer Modality at Deceased Cases Interval Diagnosis (Years) (Years) ALL FIRST CANCERS 3654 2550 Pre ESRF 1549 1033 10.25 9.52, 10.98 57.21 13.35 On Dialysis 812 662 0.86 0.72, 1.01 64.16 10.35 Post Transplantation 1293 855 2.23 1.68, 2.78 52.03 12.74 BLADDER 330 239 Pre ESRF 164 103 10.26 7.87, 12.64 59.38 11.13 On Dialysis 89 77 1.23 0.93, 1.54 64.91 8.52 Post Transplantation 77 59 3.96 2.93, 5.00 54.40 9.74 KIDNEY 545 371 Pre ESRF 364 241 9.14 7.98, 10.29 58.28 11.96 On Dialysis 90 69 1.15 0.45, 2.44 61.70 12.15 Post Transplantation 91 61 1.64 0.48, 2.81 54.57 12.56 TRACHEA, BRONCHUS, LUNG 281 262 Pre ESRF 23 18 5.07 2.67, 7.47 62.85 7.34 On Dialysis 155 147 0.26 0.18, 0.34 66.60 8.03 Post Transplantation 103 97 0.4 0.25, 0.54 60.32 9.86 COLON 315 223 Pre ESRF 150 91 10.86 9.19, 12.53 62.07 10.46 On Dialysis 72 60 0.51 0.00, 1.13 65.79 8.69 Post Transplantation 93 72 0.76 0.19, 1.33 58.63 9.53 FEMALE BREAST 365 232 Pre ESRF 193 131 11.17 8.77, 13.57 56.48 11.94 On Dialysis 92 61 2.46 1.96, 2.95 60.03 11.92 Post Transplantation 80 40 5.74 4.21, 7.27 52.15 9.59 MELANOMA 338 217 Pre ESRF 99 72 12.1 9.07, 15.12 56.05 13.57 On Dialysis 64 50 2.17 1.03, 3.31 66.88 9.56 Post Transplantation 175 95 6.46 4.19, 8.74 52.69 12.29 ALL LYMPHOMA 294 198 Pre ESRF 52 34 11.68 8.9, 14.46 52.98 15.43 On Dialysis 31 25 0.94 0.18, 1.71 61.24 9.04 Post Transplantation 211 139 0.84 0.01, 1.66 48.50 14.57

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