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Retroviral Links to Cancer

Retroviral Links to Cancer . Gilbert W Cole University of North Carolina At Charlotte Sandra Gesing Ph.D. University of Edinburgh. Regulatory Networks & miRNA. Gene Regulator Networks control the functions of the cell Molecular Signals are used for intracellular communication

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Retroviral Links to Cancer

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  1. Retroviral Links to Cancer Gilbert W Cole University of North Carolina At Charlotte Sandra GesingPh.D. University of Edinburgh

  2. Regulatory Networks & miRNA • Gene Regulator Networks control the functions of the cell • Molecular Signals are used for intracellular communication • Micro RNA (miRNA) is used as a molecular signal typically to inhibit transcription or translation of other molecular signals or genes. • Alien miRNA introduced into the cell could disrupt the regulatory networks within the cell resulting in a cancerous cell. • miRNA is typically between 18 – 25 base pairs in length

  3. Retroviruses • Retroviruses enter and infect cells as RNA the convert themselves into double stranded DNA and insert themselves into the host genome. • Once the retrovirus has inserted itself into the host genome, the host will make new copies of the virus that can infect other cells.

  4. Retroviral & miRNA • Retroviruses can pick up regions of their host during the replication process. • These regions may contain gene segments that can act as miRNA • 4 Essential genes of a retrovirus (GAG, PPT, POL and ENV) • Unspecific gene regions (U3 and U5) • Repetitive sequence regions (R) • The U3 and U5 regions are locations where miRNAs could be located

  5. GPU Search tool • Development of a GPU based search tool. • The search tool will be written in both CUDA and OpenCL to determine the most efficient GPU method for the search tool. • The algorithm will use the 4 genes, gag, ppt, pol and env to locate the retroviruses. • Once these regions are found we will search the regions beteween the 4 genes against the miRNA database for matches with high confidence. • The tool will search for both the miRNA and its reverse compliment to also find potential interfering RNAs (RNAi). When a match is found the tool will report the match location and miRNA sequence. • It is hoped that this information will help in the development of cancer treatments.

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